T-lymphocyte cycling in human cyclic neutropenia: Effects of lithium in vitro and in vivo

William Borkowsky, Louis Shenkman, Aaron Rausen

Research output: Contribution to journalArticlepeer-review

Abstract

Two patients with cyclic neutropenia demonstrated T-cell lymphopenia during their neutropenic episodes. In addition, they also demonstrated a depressed lymphocyte proliferative response to phytohemagglutinin when neutropenic, which was possibly mediated by a plasma factor. Lithium appeared to normalize T-cell expression and function when used in vitro and in vivo. Lithium therapy of one patient resulted in a cessation of T-cell cycling and a transient clinical improvement without affecting neutrophil periodicity.

Original languageEnglish
Pages (from-to)586-592
Number of pages7
JournalClinical Immunology and Immunopathology
Volume23
Issue number3
DOIs
StatePublished - Jun 1982
Externally publishedYes

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