Abstract
In a healthy body, self-reactive T cells are deleted or inactivated in the thymus. Aberrant T cell responses, however, are key in driving autoimmunity, supporting the notion that these autoreactive T cells appear to escape thymic selection. Different subsets of T cells have been implicated in mediating many aspects of autoimmune inflammation. This chapter reviews the characteristics and the main molecular pathways that participate in the development of autoreactive T cells.
| Original language | English |
|---|---|
| Title of host publication | Mosaic of Autoimmunity |
| Subtitle of host publication | The Novel Factors of Autoimmune Diseases |
| Publisher | Elsevier |
| Pages | 29-36 |
| Number of pages | 8 |
| ISBN (Electronic) | 9780128143087 |
| ISBN (Print) | 9780128143070 |
| DOIs | |
| State | Published - 13 Feb 2019 |
Keywords
- Autoreactive T cells
- CD3 zeta
- CREM/ICER
- CaMKIV
- Double-negative T cells
- MTOR
- Protein phosphatase 2A
- Regulatory T cells
- T follicular helper T cells
- Th17 cells