T-cell subsets in acute psychotic schizophrenic patients

A. Achiron*, S. Noy, E. Pras, J. Lereya, H. Hermesh, N. Laor

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


Two-color flow cytometric analysis was performed on peripheral blood lymphocytes of 16 untreated schizophrenic patients during an acute psychotic attack and 16 healthy control subjects to evaluate differences in T-cell subpopulations. In schizophrenic patients, we observed decrease in CD4+ 2H4+ (suppressor-inducer) and CD8+ 2H4+ (suppressor-effector) T-cell subsets. The selective loss of 2H4+ cell marker both on helper and suppressor T cells was not correlated to the severity of the acute psychosis. Our results may indicate a mechanism of an immune disequilibrium in schizophrenia patients during an acute psychotic attack.

Original languageEnglish
Pages (from-to)27-31
Number of pages5
JournalBiological Psychiatry
Issue number1
StatePublished - 1 Jan 1994
Externally publishedYes


  • Schizophrenia
  • T-cell subsets


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