T-Cell-Mediated cytotoxicity in patients with colorectal cancer

A. Klajman, R. Farkas, I. Drucker, M. Schneider, M. Becker, B. Man, R. Reiss

Research output: Contribution to journalArticlepeer-review


T-Cell-mediated cytotoxicity (CMC) of peripheral blood mononuclear cells from 26 patients with colorectal carcinomas (Ca) and from 26 age- and sex-matched controls was examined employing a xenogeneic chromium-51 release assay against murine mastocytoma P-815. The CMC activity of the Ca patient group was depressed compared to that of controls (P < 0.02). The percentages of T and B cells were similar in patient and control groups; optimal PHA and suboptimal Con A responses were reduced in the patient group.

Original languageEnglish
Pages (from-to)335-343
Number of pages9
JournalClinical Immunology and Immunopathology
Issue number3
StatePublished - 1980


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