T-cell acute lymphoblastic leukemia with severe leukopenia: Evidence for suppression of myeloid progenitor cells by leukemic blasts

Dan Douer; Isaac Ben-Bassat; Paul Froom; Nili Sliaked; Bracha Ramot

doi:10.1159/000205634

T-cell acute lymphoblastic leukemia with severe leukopenia: Evidence for suppression of myeloid progenitor cells by leukemic blasts

Dan Douer^*, Isaac Ben-Bassat, Paul Froom, Nili Sliaked, Bracha Ramot

^*Corresponding author for this work

Tel Aviv University

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

A patient with T-cell acute lymphoblastic leukemia presented with leukopenia due to neutropenia, no circulating blasts and normal hemoglobin level. Marrow leukemic T lymphoblasts inhibited in vitro normal CFU-GM colony growth and released an activity that stimulated normal BFU-E growth. This patient demonstrates that immature T cells may modify hematopoietic stem cell growth both in vitro and in vivo.

Original language	English
Pages (from-to)	185-189
Number of pages	5
Journal	Acta Haematologica
Volume	80
Issue number	4
DOIs	https://doi.org/10.1159/000205634
State	Published - 1988

Keywords

BFU-E
CFU-GM suppression
Hematopoiesis
Leukopenia
T-cell acute lymphoblastic leukemia

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1159/000205634

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title = "T-cell acute lymphoblastic leukemia with severe leukopenia: Evidence for suppression of myeloid progenitor cells by leukemic blasts",

abstract = "A patient with T-cell acute lymphoblastic leukemia presented with leukopenia due to neutropenia, no circulating blasts and normal hemoglobin level. Marrow leukemic T lymphoblasts inhibited in vitro normal CFU-GM colony growth and released an activity that stimulated normal BFU-E growth. This patient demonstrates that immature T cells may modify hematopoietic stem cell growth both in vitro and in vivo.",

keywords = "BFU-E, CFU-GM suppression, Hematopoiesis, Leukopenia, T-cell acute lymphoblastic leukemia",

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T2 - Evidence for suppression of myeloid progenitor cells by leukemic blasts

AU - Douer, Dan

AU - Ben-Bassat, Isaac

AU - Froom, Paul

AU - Sliaked, Nili

AU - Ramot, Bracha

PY - 1988

Y1 - 1988

N2 - A patient with T-cell acute lymphoblastic leukemia presented with leukopenia due to neutropenia, no circulating blasts and normal hemoglobin level. Marrow leukemic T lymphoblasts inhibited in vitro normal CFU-GM colony growth and released an activity that stimulated normal BFU-E growth. This patient demonstrates that immature T cells may modify hematopoietic stem cell growth both in vitro and in vivo.

AB - A patient with T-cell acute lymphoblastic leukemia presented with leukopenia due to neutropenia, no circulating blasts and normal hemoglobin level. Marrow leukemic T lymphoblasts inhibited in vitro normal CFU-GM colony growth and released an activity that stimulated normal BFU-E growth. This patient demonstrates that immature T cells may modify hematopoietic stem cell growth both in vitro and in vivo.

KW - BFU-E

KW - CFU-GM suppression

KW - Hematopoiesis

KW - Leukopenia

KW - T-cell acute lymphoblastic leukemia

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U2 - 10.1159/000205634

DO - 10.1159/000205634

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JF - Acta Haematologica

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ER -

T-cell acute lymphoblastic leukemia with severe leukopenia: Evidence for suppression of myeloid progenitor cells by leukemic blasts

Abstract

Keywords

UN SDGs

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