T-cell acute lymphoblastic leukemia with severe leukopenia: Evidence for suppression of myeloid progenitor cells by leukemic blasts

Dan Douer, Isaac Ben-Bassat, Paul Froom, Nili Sliaked, Bracha Ramot

Research output: Contribution to journalArticlepeer-review

Abstract

A patient with T-cell acute lymphoblastic leukemia presented with leukopenia due to neutropenia, no circulating blasts and normal hemoglobin level. Marrow leukemic T lymphoblasts inhibited in vitro normal CFU-GM colony growth and released an activity that stimulated normal BFU-E growth. This patient demonstrates that immature T cells may modify hematopoietic stem cell growth both in vitro and in vivo.

Original languageEnglish
Pages (from-to)185-189
Number of pages5
JournalActa Haematologica
Volume80
Issue number4
DOIs
StatePublished - 1988

Keywords

  • BFU-E
  • CFU-GM suppression
  • Hematopoiesis
  • Leukopenia
  • T-cell acute lymphoblastic leukemia

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