Systemic Side Effects of Ophthalmic Drops

Yair Levy, David Zadok

Research output: Contribution to journalArticlepeer-review


Topical application of ocular drugs may cause serious adverse ocular or systemic side effects. Children are at greater risk for systemic side effects because ocular dosing is not weight-adjusted, and infants are especially vulnerable as a consequence of the inability to efficiently metabolize the drug, and/or an immature blood-brain barrier. Four pediatric patients are reported in whom treatment with topical brimonidine, a selective alpha-2 adrenoceptor agonist, indicated for the treatment of glaucoma, produced somnolence. Anti-glaucoma eyedrops that are not approved for use in children are still used frequently in pediatrics. Therefore, physicians should be aware of possible systemic side effects of ophthalmic drops.

Original languageEnglish
Pages (from-to)99-101
Number of pages3
JournalClinical Pediatrics
Issue number1
StatePublished - Jan 2004


Dive into the research topics of 'Systemic Side Effects of Ophthalmic Drops'. Together they form a unique fingerprint.

Cite this