Systemic Prophylactic Antibiotics in Elective Biliary Surgery

Zvi Kaufman, Moshe Engelberg, Avinoam Eliashiv, Raphael Reiss

Research output: Contribution to journalArticlepeer-review


• We tested the effectiveness of prophylactic antibiotics in elective cholecystectomy in 105 patients in a single-blind, controlled randomized trial. Fifty-six patients received prophylactic antibiotics and 49 patients entered the control group. Of the patients who received prophylactic antibiotics, 3.6% had wound infections, v 24.5% in the control group. The rate of wound infection in patients with positive bile cultures, diabetes, appendectomies, and choledochotomies was 24.4%, v 3.4% in the group who had cholecystectomies only, with negative bile cultures and no diabetes. We concluded that prophylactic antibiotics are effective in patients with high-risk factors such as diabetes mellitus, exploration of the choledochus, and appendectomy, and in patients with positive bile cultures.

Original languageEnglish
Pages (from-to)1002-1004
Number of pages3
JournalArchives of Surgery
Issue number9
StatePublished - Sep 1984


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