SYSTEMIC KETOCONAZOLE TREATMENT FOR FUSARIUM LEG ULCERS

MARINA LANDAU, AVIGDOR SREBRNIK, RONNI WOLF, EDNA BASHI, SARAH BRENNER

Research output: Contribution to journalArticlepeer-review

Abstract

Fusarium oxysporum was isolated from a large foot ulcer in an otherwise healthy 69‐year‐old man. Although tissue invasion could not be proven histologically, systemic antifun‐gal treatment was administered with satisfactory response. Fusarium species are common soil‐inhabiting organisms and plant pathogens. In humans, Fusarium is considered an opportunistic agent in skin ulcers, interdigital spaces, and burned skin, but can also cause mycotic keratitis, onychomycosis, and rarely deep‐seated or disseminated infections, especially in an immunocompromised host. The distinction between skin infection and saprophytic growth, as well as optimal treatment regimens for the two types of infection, have not been clearly defined. We describe a case of leg ulcers caused by Fusarium oxysporum in a 69‐year‐old man treated successfully with oral ketoconazole. “Silent” immunologic disturbances were found in this apparently healthy patient. The case illustrates a relatively benign infection caused by Fusarium that responded to systemic antifungal drug treatment.

Original languageEnglish
Pages (from-to)511-512
Number of pages2
JournalInternational Journal of Dermatology
Volume31
Issue number7
DOIs
StatePublished - Jul 1992

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