TY - JOUR
T1 - Systemic integration of different inheritance systems
AU - Jablonka, Eva
AU - Noble, Denis
N1 - Publisher Copyright:
© 2018
PY - 2019/2
Y1 - 2019/2
N2 - The between-generations transmission of phenotypic variations is based on networks operating at different levels–genetic, epigenetic, behavioral and symbolic. Since each level involves a network of interactions, integrating such networks of networks may seem hopelessly complex. We suggest that the problem can be drastically simplified if analysis starts from a description of the heritable trait of interest as an attractor in a developmental landscape constructed by networks of inputs at underlying and overlying levels of organization. On this basis, further studies quantifying the different inputs that contribute to the between-generational re-construction of the trait can be made and enable the development of a systemic, dynamic and predictive model of inheritance.
AB - The between-generations transmission of phenotypic variations is based on networks operating at different levels–genetic, epigenetic, behavioral and symbolic. Since each level involves a network of interactions, integrating such networks of networks may seem hopelessly complex. We suggest that the problem can be drastically simplified if analysis starts from a description of the heritable trait of interest as an attractor in a developmental landscape constructed by networks of inputs at underlying and overlying levels of organization. On this basis, further studies quantifying the different inputs that contribute to the between-generational re-construction of the trait can be made and enable the development of a systemic, dynamic and predictive model of inheritance.
KW - Canalization
KW - Developmental systems theory (DST)
KW - Heritably varying trait (HVT)
KW - Inclusive inheritance
KW - Inheritance systems
KW - Landscape model
KW - Price equation
KW - Waddington
UR - http://www.scopus.com/inward/record.url?scp=85055906007&partnerID=8YFLogxK
U2 - 10.1016/j.coisb.2018.10.002
DO - 10.1016/j.coisb.2018.10.002
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AN - SCOPUS:85055906007
VL - 13
SP - 52
EP - 58
JO - Current Opinion in Systems Biology
JF - Current Opinion in Systems Biology
SN - 2452-3100
ER -