Abstract
The between-generations transmission of phenotypic variations is based on networks operating at different levels–genetic, epigenetic, behavioral and symbolic. Since each level involves a network of interactions, integrating such networks of networks may seem hopelessly complex. We suggest that the problem can be drastically simplified if analysis starts from a description of the heritable trait of interest as an attractor in a developmental landscape constructed by networks of inputs at underlying and overlying levels of organization. On this basis, further studies quantifying the different inputs that contribute to the between-generational re-construction of the trait can be made and enable the development of a systemic, dynamic and predictive model of inheritance.
Original language | English |
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Pages (from-to) | 52-58 |
Number of pages | 7 |
Journal | Current Opinion in Systems Biology |
Volume | 13 |
DOIs | |
State | Published - Feb 2019 |
Keywords
- Canalization
- Developmental systems theory (DST)
- Heritably varying trait (HVT)
- Inclusive inheritance
- Inheritance systems
- Landscape model
- Price equation
- Waddington