Systematic review of treatment effectiveness and outcome measures for enthesitis in psoriatic arthritis

Ana Maria Orbai; Joshua Weitz; Evan L. Siegel; Stefan Siebert; Laura J. Savage; Sibel Z. Aydin; Jolanda J. Luime; Ori Elkayam; Barbara Neerinckx; Slavo Urbancek; Kurt De Vlam; Christopher T. Ritchlin

doi:10.3899/jrheum.140878

Systematic review of treatment effectiveness and outcome measures for enthesitis in psoriatic arthritis

Ana Maria Orbai^*, Joshua Weitz, Evan L. Siegel, Stefan Siebert, Laura J. Savage, Sibel Z. Aydin, Jolanda J. Luime, Ori Elkayam, Barbara Neerinckx, Slavo Urbancek, Kurt De Vlam, Christopher T. Ritchlin

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

Abstract

Enthesitis is a characteristic feature of psoriatic arthritis (PsA) and is important in disease pathogenesis and classification. Use of clinical outcome measures for enthesitis is heterogeneous, and only 1 measure has been specifically developed and validated in PsA. Ultrasound and magnetic resonance imaging assessments of enthesitis may have advantages over clinical examination but are insufficiently studied. As part of an update of treatment recommendations by the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA), we performed a systematic literature review and identified randomized controlled trials with enthesitis outcomes in PsA. For each treatment agent we calculated treatment effect sizes (where applicable) and graded the level of evidence.

Original language	English
Pages (from-to)	2290-2294
Number of pages	5
Journal	Journal of Rheumatology
Volume	41
Issue number	11
DOIs	https://doi.org/10.3899/jrheum.140878
State	Published - 1 Nov 2014
Externally published	Yes

Keywords

Enthesitis
Enthesopathy psoriatic arthritis
Outcome measures
Treatment

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10.3899/jrheum.140878

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abstract = "Enthesitis is a characteristic feature of psoriatic arthritis (PsA) and is important in disease pathogenesis and classification. Use of clinical outcome measures for enthesitis is heterogeneous, and only 1 measure has been specifically developed and validated in PsA. Ultrasound and magnetic resonance imaging assessments of enthesitis may have advantages over clinical examination but are insufficiently studied. As part of an update of treatment recommendations by the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA), we performed a systematic literature review and identified randomized controlled trials with enthesitis outcomes in PsA. For each treatment agent we calculated treatment effect sizes (where applicable) and graded the level of evidence.",

keywords = "Enthesitis, Enthesopathy psoriatic arthritis, Outcome measures, Treatment",

author = "Orbai, {Ana Maria} and Joshua Weitz and Siegel, {Evan L.} and Stefan Siebert and Savage, {Laura J.} and Aydin, {Sibel Z.} and Luime, {Jolanda J.} and Ori Elkayam and Barbara Neerinckx and Slavo Urbancek and {De Vlam}, Kurt and Ritchlin, {Christopher T.}",

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AU - Orbai, Ana Maria

AU - Weitz, Joshua

AU - Siegel, Evan L.

AU - Siebert, Stefan

AU - Savage, Laura J.

AU - Aydin, Sibel Z.

AU - Luime, Jolanda J.

AU - Elkayam, Ori

AU - Neerinckx, Barbara

AU - Urbancek, Slavo

AU - De Vlam, Kurt

AU - Ritchlin, Christopher T.

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AB - Enthesitis is a characteristic feature of psoriatic arthritis (PsA) and is important in disease pathogenesis and classification. Use of clinical outcome measures for enthesitis is heterogeneous, and only 1 measure has been specifically developed and validated in PsA. Ultrasound and magnetic resonance imaging assessments of enthesitis may have advantages over clinical examination but are insufficiently studied. As part of an update of treatment recommendations by the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA), we performed a systematic literature review and identified randomized controlled trials with enthesitis outcomes in PsA. For each treatment agent we calculated treatment effect sizes (where applicable) and graded the level of evidence.

KW - Enthesitis

KW - Enthesopathy psoriatic arthritis

KW - Outcome measures

KW - Treatment

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Systematic review of treatment effectiveness and outcome measures for enthesitis in psoriatic arthritis

Abstract

Keywords

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