TY - JOUR
T1 - Systematic review and meta-analysis of the association between β2-adrenoceptor polymorphisms and asthma
T2 - A HuGE review
AU - Thakkinstian, Ammarin
AU - McEvoy, Mark
AU - Minelli, Cosetta
AU - Gibson, Peter
AU - Hancox, Bob
AU - Duffy, David
AU - Thompson, John
AU - Hall, Ian
AU - Kaufman, Joel
AU - Leung, Ting Fan
AU - Helms, Peter Joseph
AU - Hakonarson, Hakon
AU - Halpi, Eva
AU - Navon, Ruth
AU - Attia, John
PY - 2005/8
Y1 - 2005/8
N2 - A number of studies have investigated two common polymorphisms in the β2-adrenoceptor gene, Arg/Gly16 and Gln/Glu27, in relation to asthma susceptibility. The authors performed a meta-analysis of each polymorphism, as well as haplotype analysis, for adult and pediatric populations separately, using published data, supplemented by additional data requested from the original authors. Individual analysis detected no effect of Arg/Gly16 in adults but did suggest a recessive protective effect of Gly16 for children, with an odds ratio of 0.71 (95% confidence interval (CI): 0.53, 0.96) compared with the other genotypes. Results for Gln/Glu27 in adults seem to indicate that heterozygotes are at decreased risk of asthma than either homozygote (odds ratio = 0.73, 95% CI: 0.62, 0.87), although the studies are heterogeneous; in children, the Glu/Glu genotype has a decreased risk of asthma (odds ratio = 0.60, 95% CI: 0.35, 0.99) compared with the other genotypes. Despite the proximity of these two polymorphic sites, the linkage disequilibrium coefficient of 0.41 was not high (p < 0.001). Haplotype analysis suggests that there may be an interaction between the two sites, with a lower risk of asthma associated with the Glu27 allele (compared with Gln27), and that this risk is modified by the allele at position 16.
AB - A number of studies have investigated two common polymorphisms in the β2-adrenoceptor gene, Arg/Gly16 and Gln/Glu27, in relation to asthma susceptibility. The authors performed a meta-analysis of each polymorphism, as well as haplotype analysis, for adult and pediatric populations separately, using published data, supplemented by additional data requested from the original authors. Individual analysis detected no effect of Arg/Gly16 in adults but did suggest a recessive protective effect of Gly16 for children, with an odds ratio of 0.71 (95% confidence interval (CI): 0.53, 0.96) compared with the other genotypes. Results for Gln/Glu27 in adults seem to indicate that heterozygotes are at decreased risk of asthma than either homozygote (odds ratio = 0.73, 95% CI: 0.62, 0.87), although the studies are heterogeneous; in children, the Glu/Glu genotype has a decreased risk of asthma (odds ratio = 0.60, 95% CI: 0.35, 0.99) compared with the other genotypes. Despite the proximity of these two polymorphic sites, the linkage disequilibrium coefficient of 0.41 was not high (p < 0.001). Haplotype analysis suggests that there may be an interaction between the two sites, with a lower risk of asthma associated with the Glu27 allele (compared with Gln27), and that this risk is modified by the allele at position 16.
KW - Asthma
KW - Epidemiology
KW - Genetics
KW - Haplotypes
KW - Linkage disequilibrium
KW - Meta-analysis
KW - Polymorphism, genetic
KW - Receptors, adrenergic
UR - http://www.scopus.com/inward/record.url?scp=24144436042&partnerID=8YFLogxK
U2 - 10.1093/aje/kwi184
DO - 10.1093/aje/kwi184
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AN - SCOPUS:24144436042
SN - 0002-9262
VL - 162
SP - 201
EP - 211
JO - American Journal of Epidemiology
JF - American Journal of Epidemiology
IS - 3
ER -