Systematic Comparison of Muscle Ultrasound Thickness in Polyneuropathies and Other Neuromuscular Diseases

Sara A. Alnajjar, Davood Fathihelabad, Alon Abraham, Lubna Daniyal, Leif Erik Lovblom, Vera Bril*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Background: We have aimed to assess whether muscle thickness ultrasound (US) shows differences between patients with chronic inflammatory demyelinating polyneuropathy (CIDP), chronic axonal polyneuropathy (CAP), and other neuromuscular (NM) diseases compared to controls and to each other. Methods: We performed a cross-sectional study from September 2021 to June 2022. All subjects underwent quantitative sonographic evaluation of muscle thickness in eight relaxed muscles and four contracted muscles. Differences were assessed using multivariable linear regression, correcting for age and body mass index (BMI). Results: The study cohort consisted of 65 healthy controls, and 95 patients: 31 with CIDP, 34 with CAP, and 30 with other NM diseases. Both relaxed and contracted muscle thickness in all patient groups were lower than in the healthy controls, after controlling for age and body mass index (BMI). Regression confirmed that the differences persisted between patient groups and healthy controls. Differences between patient groups were not apparent. Conclusion: The current study shows that muscle ultrasound thickness is not specific in NM disorders, but shows a global reduction in thickness compared with healthy controls after corrections for age and BMI.

Original languageEnglish
Pages (from-to)1623-1630
Number of pages8
JournalNeurology and Therapy
Issue number5
StatePublished - Oct 2023


  • Diagnosis
  • Monitoring
  • Muscle
  • Polyneuropathy
  • Ultrasound


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