Synthetic cannabinoids revealing adrenoleukodystrophy

Avi Fellner; Felix Benninger; Ruth Djaldetti

doi:10.1016/j.jocn.2015.07.020

Synthetic cannabinoids revealing adrenoleukodystrophy

Avi Fellner^*, Felix Benninger, Ruth Djaldetti

^*Corresponding author for this work

Clinical Departments

Research output: Contribution to journal › Article › peer-review

Abstract

We report a 41-year-old man who presented with a first generalized tonic-clonic seizure after recent consumption of a synthetic cannabinoid. MRI showed extensive bilateral, mainly frontal, white matter lesions. Blood analysis for very long chain fatty acids was compatible with adrenoleukodystrophy, and a missense mutation in the ABCD1 gene confirmed the diagnosis. We hypothesize that cannabinoid use might have contributed to metabolic decompensation with subacute worsening of the underlying condition.

Original language	English
Pages (from-to)	155-156
Number of pages	2
Journal	Journal of Clinical Neuroscience
Volume	24
DOIs	https://doi.org/10.1016/j.jocn.2015.07.020
State	Published - 1 Feb 2016

Keywords

Adrenoleukodystrophy
Cannabinoids
Leukodystrophies
MRI
Seizures

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10.1016/j.jocn.2015.07.020

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title = "Synthetic cannabinoids revealing adrenoleukodystrophy",

abstract = "We report a 41-year-old man who presented with a first generalized tonic-clonic seizure after recent consumption of a synthetic cannabinoid. MRI showed extensive bilateral, mainly frontal, white matter lesions. Blood analysis for very long chain fatty acids was compatible with adrenoleukodystrophy, and a missense mutation in the ABCD1 gene confirmed the diagnosis. We hypothesize that cannabinoid use might have contributed to metabolic decompensation with subacute worsening of the underlying condition.",

keywords = "Adrenoleukodystrophy, Cannabinoids, Leukodystrophies, MRI, Seizures",

author = "Avi Fellner and Felix Benninger and Ruth Djaldetti",

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AU - Benninger, Felix

AU - Djaldetti, Ruth

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N2 - We report a 41-year-old man who presented with a first generalized tonic-clonic seizure after recent consumption of a synthetic cannabinoid. MRI showed extensive bilateral, mainly frontal, white matter lesions. Blood analysis for very long chain fatty acids was compatible with adrenoleukodystrophy, and a missense mutation in the ABCD1 gene confirmed the diagnosis. We hypothesize that cannabinoid use might have contributed to metabolic decompensation with subacute worsening of the underlying condition.

AB - We report a 41-year-old man who presented with a first generalized tonic-clonic seizure after recent consumption of a synthetic cannabinoid. MRI showed extensive bilateral, mainly frontal, white matter lesions. Blood analysis for very long chain fatty acids was compatible with adrenoleukodystrophy, and a missense mutation in the ABCD1 gene confirmed the diagnosis. We hypothesize that cannabinoid use might have contributed to metabolic decompensation with subacute worsening of the underlying condition.

KW - Adrenoleukodystrophy

KW - Cannabinoids

KW - Leukodystrophies

KW - MRI

KW - Seizures

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JO - Journal of Clinical Neuroscience

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ER -

Synthetic cannabinoids revealing adrenoleukodystrophy

Abstract

Keywords

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