Synthetic cannabinoids revealing adrenoleukodystrophy

Avi Fellner*, Felix Benninger, Ruth Djaldetti

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


We report a 41-year-old man who presented with a first generalized tonic-clonic seizure after recent consumption of a synthetic cannabinoid. MRI showed extensive bilateral, mainly frontal, white matter lesions. Blood analysis for very long chain fatty acids was compatible with adrenoleukodystrophy, and a missense mutation in the ABCD1 gene confirmed the diagnosis. We hypothesize that cannabinoid use might have contributed to metabolic decompensation with subacute worsening of the underlying condition.

Original languageEnglish
Pages (from-to)155-156
Number of pages2
JournalJournal of Clinical Neuroscience
StatePublished - 1 Feb 2016


  • Adrenoleukodystrophy
  • Cannabinoids
  • Leukodystrophies
  • MRI
  • Seizures


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