Synthesis of DNA-based nanowires

Alexander Kotlyar

doi:10.1007/978-1-4939-8582-1_3

Synthesis of DNA-based nanowires

Alexander Kotlyar^*

^*Corresponding author for this work

Biochemistry Molecular Biology

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

2 Scopus citations

Abstract

Here we describe novel enzymatic procedures for the production of long (from tens of nanometers to microns) double-stranded poly(dG)–poly(dC), triple-helical poly(dG)–poly(dG)–poly(dC), and quadruple-helical G4 DNA. All these molecules are uniform in size and possess improved mechanical and electrical properties with respect to a canonical random sequence double-stranded DNA. They can potentially be used as elements in nanoelectronic devices and circuits.

Original language	English
Title of host publication	Methods in Molecular Biology
Publisher	Humana Press Inc.
Pages	23-47
Number of pages	25
DOIs	https://doi.org/10.1007/978-1-4939-8582-1_3
State	Published - 2018

Publication series

Name	Methods in Molecular Biology
Volume	1811
ISSN (Print)	1064-3745

Funding

Funders	Funder number
Israel Science Foundation	1589/14

Keywords

DNA nanowires
Enzymatic synthesis
G4-DNA
Klenow exo
Poly(dG)–poly(dC)
Triplex DNA

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10.1007/978-1-4939-8582-1_3

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keywords = "DNA nanowires, Enzymatic synthesis, G4-DNA, Klenow exo, Poly(dG)–poly(dC), Triplex DNA",

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AB - Here we describe novel enzymatic procedures for the production of long (from tens of nanometers to microns) double-stranded poly(dG)–poly(dC), triple-helical poly(dG)–poly(dG)–poly(dC), and quadruple-helical G4 DNA. All these molecules are uniform in size and possess improved mechanical and electrical properties with respect to a canonical random sequence double-stranded DNA. They can potentially be used as elements in nanoelectronic devices and circuits.

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KW - Enzymatic synthesis

KW - G4-DNA

KW - Klenow exo

KW - Poly(dG)–poly(dC)

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Synthesis of DNA-based nanowires

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