Synthesis of DNA-based nanowires

Alexander Kotlyar*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


Here we describe novel enzymatic procedures for the production of long (from tens of nanometers to microns) double-stranded poly(dG)–poly(dC), triple-helical poly(dG)–poly(dG)–poly(dC), and quadruple-helical G4 DNA. All these molecules are uniform in size and possess improved mechanical and electrical properties with respect to a canonical random sequence double-stranded DNA. They can potentially be used as elements in nanoelectronic devices and circuits.

Original languageEnglish
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Number of pages25
StatePublished - 2018

Publication series

NameMethods in Molecular Biology
ISSN (Print)1064-3745


  • DNA nanowires
  • Enzymatic synthesis
  • G4-DNA
  • Klenow exo
  • Poly(dG)–poly(dC)
  • Triplex DNA


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