Synthesis of difluoroaryldioxoles using BrF3

Youlia Hagooly, Michael J. Welch, Shlomo Rozen

Research output: Contribution to journalArticlepeer-review


A novel synthesis of different aromatic and heteroaromatic difluorodioxole derivatives has been developed. The starting materials were catechols, which, after treatment with thiophosgene, formed at 0 °C the respective thiodioxoles. The latter were reacted for a short time with commercially available bromine trifluoride, producing potentially biologically important difluoroaryldioxoles in moderate to high yields.

Original languageEnglish
Pages (from-to)902-905
Number of pages4
JournalOrganic and Biomolecular Chemistry
Issue number3
StatePublished - 7 Feb 2011


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