Synthesis of chondromucoprotein by chondrocytes in suspension culture

Zvi Nevo, Allen L. Horwitz, Albert Dorfmann

Research output: Contribution to journalArticlepeer-review

Abstract

Embryonic chick chondrocytes growing in suspension culture excrete into the medium chondromucoprotein which appears to be identical to chondromucoprotein isolated from epiphyseal cartilage. Low oxygen tension favored maximum production of chondromucoprotein. The presence of ascorbic acid enhanced both chondromucoprotein and collagen synthesis. Glycosyltransferases involved in chondromucoprotein synthesis were detected in homogenates of such cultured chondrocytes.

Original languageEnglish
Pages (from-to)219-228
Number of pages10
JournalDevelopmental Biology
Volume28
Issue number1
DOIs
StatePublished - May 1972
Externally publishedYes

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