Synthesis of chondromucoprotein by chondrocytes in suspension culture

Zvi Nevo; Allen L. Horwitz; Albert Dorfmann

doi:10.1016/0012-1606(72)90139-X

Synthesis of chondromucoprotein by chondrocytes in suspension culture

Zvi Nevo^*, Allen L. Horwitz, Albert Dorfmann

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Embryonic chick chondrocytes growing in suspension culture excrete into the medium chondromucoprotein which appears to be identical to chondromucoprotein isolated from epiphyseal cartilage. Low oxygen tension favored maximum production of chondromucoprotein. The presence of ascorbic acid enhanced both chondromucoprotein and collagen synthesis. Glycosyltransferases involved in chondromucoprotein synthesis were detected in homogenates of such cultured chondrocytes.

Original language	English
Pages (from-to)	219-228
Number of pages	10
Journal	Developmental Biology
Volume	28
Issue number	1
DOIs	https://doi.org/10.1016/0012-1606(72)90139-X
State	Published - May 1972
Externally published	Yes

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title = "Synthesis of chondromucoprotein by chondrocytes in suspension culture",

abstract = "Embryonic chick chondrocytes growing in suspension culture excrete into the medium chondromucoprotein which appears to be identical to chondromucoprotein isolated from epiphyseal cartilage. Low oxygen tension favored maximum production of chondromucoprotein. The presence of ascorbic acid enhanced both chondromucoprotein and collagen synthesis. Glycosyltransferases involved in chondromucoprotein synthesis were detected in homogenates of such cultured chondrocytes.",

author = "Zvi Nevo and Horwitz, {Allen L.} and Albert Dorfmann",

note = "Funding Information: {\textquoteleft}These studies were supported by Grants AM-05996 and HD-04583 from the United States Public Health Service and a grant from the Chicago and Illinois Heart Association.",

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doi = "10.1016/0012-1606(72)90139-X",

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N2 - Embryonic chick chondrocytes growing in suspension culture excrete into the medium chondromucoprotein which appears to be identical to chondromucoprotein isolated from epiphyseal cartilage. Low oxygen tension favored maximum production of chondromucoprotein. The presence of ascorbic acid enhanced both chondromucoprotein and collagen synthesis. Glycosyltransferases involved in chondromucoprotein synthesis were detected in homogenates of such cultured chondrocytes.

AB - Embryonic chick chondrocytes growing in suspension culture excrete into the medium chondromucoprotein which appears to be identical to chondromucoprotein isolated from epiphyseal cartilage. Low oxygen tension favored maximum production of chondromucoprotein. The presence of ascorbic acid enhanced both chondromucoprotein and collagen synthesis. Glycosyltransferases involved in chondromucoprotein synthesis were detected in homogenates of such cultured chondrocytes.

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Synthesis of chondromucoprotein by chondrocytes in suspension culture

Abstract

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