Synthesis of aminoglycosides

Yifat Berkov-Zrihen*, Micha Fridman

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

Aminoglycosides (AGs) are broad-spectrum antibiotics commonly used for the treatment of serious bacterial infections. These antibacterial agents target the prokaryotic ribosome by binding to the decoding A-site of the 16S ribosomal RNA (rRNA) and interfering with the protein translation process [1-5]. Following the isolation of the first known AG, streptomycin, from Streptomyces griseus by Schatz and Waksman [6] in 1944, multiple natural AGs with high structural diversity have been discovered (Figure 1). All AGs are composed of one or more carbohydrate units and contain a single pseudo-sugar aminocyclitol ring.

Original languageEnglish
Title of host publicationModern Synthetic Methods in Carbohydrate Chemistry
Subtitle of host publicationFrom Monosaccharides to Complex Glycoconjugates
PublisherWiley-VCH Verlag
Pages161-190
Number of pages30
ISBN (Electronic)9783527658947
ISBN (Print)9783527332847
DOIs
StatePublished - 18 Oct 2013

Keywords

  • A-site targeting antibiotics
  • Aminoglycoside antibiotics
  • Aminoglycoside cationic amphiphiles
  • Aminoglycoside read-through activity
  • Aminoglycoside resistance
  • Semisynthetic aminoglycosides

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