Synthesis of aminoglycosides

Yifat Berkov-Zrihen; Micha Fridman

doi:10.1002/9783527658947.ch6

Synthesis of aminoglycosides

Yifat Berkov-Zrihen^*, Micha Fridman

^*Corresponding author for this work

School of Chemistry

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Aminoglycosides (AGs) are broad-spectrum antibiotics commonly used for the treatment of serious bacterial infections. These antibacterial agents target the prokaryotic ribosome by binding to the decoding A-site of the 16S ribosomal RNA (rRNA) and interfering with the protein translation process [1-5]. Following the isolation of the first known AG, streptomycin, from Streptomyces griseus by Schatz and Waksman [6] in 1944, multiple natural AGs with high structural diversity have been discovered (Figure 1). All AGs are composed of one or more carbohydrate units and contain a single pseudo-sugar aminocyclitol ring.

Original language	English
Title of host publication	Modern Synthetic Methods in Carbohydrate Chemistry
Subtitle of host publication	From Monosaccharides to Complex Glycoconjugates
Publisher	Wiley-VCH Verlag
Pages	161-190
Number of pages	30
ISBN (Electronic)	9783527658947
ISBN (Print)	9783527332847
DOIs	https://doi.org/10.1002/9783527658947.ch6
State	Published - 18 Oct 2013

Keywords

A-site targeting antibiotics
Aminoglycoside antibiotics
Aminoglycoside cationic amphiphiles
Aminoglycoside read-through activity
Aminoglycoside resistance
Semisynthetic aminoglycosides

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Synthesis of aminoglycosides

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