Synthesis of a Zirconium Complex of an N, O-type p- tert-Butylcalix[4]arene and Its Application in Some Multicomponent Reactions

Varun Rawat*, Arkadi Vigalok, Anshu Kumar Sinha, Garima Sachdeva, Chandra Mohan Srivastava, Gyandshwar K. Rao*, Arun Kumar, Mandeep Singh, Komal Rathi, Ved Prakash Verma*, Bhupender Yadav, Amit Kumar Pandey, Monika Vats*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

The synthesis and characterization of a new octahedral Zr(IV) complex of oxygen-depleted N,O-type calixarene ligand comprising two distal-functionalized pyrazole rings have been reported. The cone shape and structure of the prepared complex were confirmed univocally by single-crystal X-ray diffraction and NMR studies. The Zr metal lies at 2.091 Å from the plane of the calixarene ring. This complex has been utilized as an efficient catalyst for the synthesis of Biginelli adducts, bis(indolyl)methanes, and coumarins. This complex (Cl2Zr-calixarene) showed superior activity for these multicomponent reactions in comparison to the corresponding Ti(IV) and Zn(II) analogues. Ferrocene-appended bis(indolyl)methane, prepared using this catalyst, was also evaluated for its anticancer activity against the A-172 cell line.

Original languageEnglish
Pages (from-to)28471-28480
Number of pages10
JournalACS Omega
Volume7
Issue number32
DOIs
StatePublished - 16 Aug 2022

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