Synthesis and Properties of Novel Silver-Containing DNA Molecules

Gennady Eidelshtein, Natalie Fardian-Melamed, Vitaly Gutkin, Dmitry Basmanov, Dmitry Klinov, Dvir Rotem, Yael Levi-Kalisman, Danny Porath*, Alexander Kotlyar

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

35 Scopus citations


An experiment was conducted to show that imaging analysis that incubation of oligonucleotide-coated 15 nm (in diameter) silver NPs (AgNPs) with poly(dG)-poly(dC) DNA yields uniform DNA-based molecules whose length is shorter by one-third and the height is larger by about one-third than that of the parent DNA. Incubation of poly(dG)-poly(dC) DNA with 15 nm spherical AgNPs coated with (dA)10 , an oligonucleotide composed of ten deoxyadenosines, leads to noticeable changes in morphology of the dsDNA, measured by AFM. It is clearly seen that DNA-based molecules obtained by the incubation are smooth, uniform, less wavy, and more rigid as compared to the parent DNA. The analysis reveals the height increase, as well as a clear height-length correlation within each one of the two types of molecules. Co-deposition enables a true comparison between both molecule populations, since their morphological features are not scan-dependent and attained under the same measuring conditions

Original languageEnglish
Pages (from-to)4839-4844
Number of pages6
JournalAdvanced Materials
Issue number24
StatePublished - Jun 2016


  • DNA nanostructures
  • DNA nanotechnology
  • DNA-metallization
  • molecular electronics
  • poly(dG)-poly(dC)
  • silver nanoparticles


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