TY - JOUR
T1 - Synthesis and Properties of Novel Silver-Containing DNA Molecules
AU - Eidelshtein, Gennady
AU - Fardian-Melamed, Natalie
AU - Gutkin, Vitaly
AU - Basmanov, Dmitry
AU - Klinov, Dmitry
AU - Rotem, Dvir
AU - Levi-Kalisman, Yael
AU - Porath, Danny
AU - Kotlyar, Alexander
PY - 2016/6
Y1 - 2016/6
N2 - An experiment was conducted to show that imaging analysis that incubation of oligonucleotide-coated 15 nm (in diameter) silver NPs (AgNPs) with poly(dG)-poly(dC) DNA yields uniform DNA-based molecules whose length is shorter by one-third and the height is larger by about one-third than that of the parent DNA. Incubation of poly(dG)-poly(dC) DNA with 15 nm spherical AgNPs coated with (dA)10 , an oligonucleotide composed of ten deoxyadenosines, leads to noticeable changes in morphology of the dsDNA, measured by AFM. It is clearly seen that DNA-based molecules obtained by the incubation are smooth, uniform, less wavy, and more rigid as compared to the parent DNA. The analysis reveals the height increase, as well as a clear height-length correlation within each one of the two types of molecules. Co-deposition enables a true comparison between both molecule populations, since their morphological features are not scan-dependent and attained under the same measuring conditions
AB - An experiment was conducted to show that imaging analysis that incubation of oligonucleotide-coated 15 nm (in diameter) silver NPs (AgNPs) with poly(dG)-poly(dC) DNA yields uniform DNA-based molecules whose length is shorter by one-third and the height is larger by about one-third than that of the parent DNA. Incubation of poly(dG)-poly(dC) DNA with 15 nm spherical AgNPs coated with (dA)10 , an oligonucleotide composed of ten deoxyadenosines, leads to noticeable changes in morphology of the dsDNA, measured by AFM. It is clearly seen that DNA-based molecules obtained by the incubation are smooth, uniform, less wavy, and more rigid as compared to the parent DNA. The analysis reveals the height increase, as well as a clear height-length correlation within each one of the two types of molecules. Co-deposition enables a true comparison between both molecule populations, since their morphological features are not scan-dependent and attained under the same measuring conditions
KW - DNA nanostructures
KW - DNA nanotechnology
KW - DNA-metallization
KW - molecular electronics
KW - poly(dG)-poly(dC)
KW - silver nanoparticles
UR - http://www.scopus.com/inward/record.url?scp=84975087494&partnerID=8YFLogxK
U2 - 10.1002/adma.201505049
DO - 10.1002/adma.201505049
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C2 - 27116695
AN - SCOPUS:84975087494
SN - 0935-9648
VL - 28
SP - 4839
EP - 4844
JO - Advanced Materials
JF - Advanced Materials
IS - 24
ER -