Synthesis and evaluation of membrane permeabilizing properties of cationic amphiphiles derived from the disaccharide trehalose

P. Shaul, R. I. Benhamou, I. M. Herzog, S. Louzoun Zada, Y. Ebenstein, M. Fridman

Research output: Contribution to journalArticlepeer-review

Abstract

Cationic amphiphiles derived from trehalose have been synthesized; trehalose analogues substituted with n-pentyl or n-hexyl ethers exhibited membrane disrupting activities against clinically important Gram positive and Gram negative bacteria and fungi. Our results demonstrate that trehalose is a useful disaccharide scaffold for the development of broad-spectrum antimicrobial and antifungal agents.

Original languageEnglish
Pages (from-to)3012-3015
Number of pages4
JournalOrganic and Biomolecular Chemistry
Volume14
Issue number11
DOIs
StatePublished - 2016

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