TY - JOUR
T1 - Synthesis and electrophilic substitution of pyrido[2,3,4-kl]-acridines
AU - Koller, Avi
AU - Rudi, Amira
AU - Garcia Gravalos, Marta
AU - Kashman, Yoel
PY - 2001/4
Y1 - 2001/4
N2 - Several new pyrido[2,3,4-kl]acridines were synthesized by reacting naphthoquinone, juglone or cyclohexan-1,3-dione with β,β'- diaminoketones in a biomimetic reaction. The structure of all new compounds was elucidated by NMR and MS spectroscopy. Electrophilic substitution, mainly nitration, of the various compounds was undertaken and the substitution positions determined. A series of derivatives was prepared and their cytotoxicity towards P-388 mouse lymphoma cells analysed. The most cytotoxic derivatives were found to have IC50's of 0.05 and 0.1 ug/ml.
AB - Several new pyrido[2,3,4-kl]acridines were synthesized by reacting naphthoquinone, juglone or cyclohexan-1,3-dione with β,β'- diaminoketones in a biomimetic reaction. The structure of all new compounds was elucidated by NMR and MS spectroscopy. Electrophilic substitution, mainly nitration, of the various compounds was undertaken and the substitution positions determined. A series of derivatives was prepared and their cytotoxicity towards P-388 mouse lymphoma cells analysed. The most cytotoxic derivatives were found to have IC50's of 0.05 and 0.1 ug/ml.
KW - Biomimetic synthesis
KW - Cytotoxicity
KW - Electrophilic nitration
KW - NMR
KW - Pyrido[2,3,4-kl]acridines
UR - http://www.scopus.com/inward/record.url?scp=0347339534&partnerID=8YFLogxK
U2 - 10.3390/60400300
DO - 10.3390/60400300
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AN - SCOPUS:0347339534
SN - 1420-3049
VL - 6
SP - 300
EP - 322
JO - Molecules
JF - Molecules
IS - 4
ER -