Synthesis and biological activity of analogues of ptilomycalin A

Gregory P. Black, Simon J. Coles, Amnon Hizi, Andrew G. Howard-Jones, Michael B. Hursthouse, Alan T. McGown, Shoshana Loya, Christopher G. Moore, Patrick J. Murphy, Nigel K. Smith, Nigel D.A. Walshe

Research output: Contribution to journalArticlepeer-review


Benzo-fused model compounds 21a and 21b, resembling in structure the marine metabolite ptilomycalin A, were prepared and were shown to display significant activity against a series of cancer cell lines and to also possess a significant activity against the DNA polymerase activity of the reverse transcriptase of human immunodeficiency virus type 1 (HIV-1 RT).

Original languageEnglish
Pages (from-to)3377-3381
Number of pages5
JournalTetrahedron Letters
Issue number19
StatePublished - 7 May 2001


Dive into the research topics of 'Synthesis and biological activity of analogues of ptilomycalin A'. Together they form a unique fingerprint.

Cite this