TY - JOUR
T1 - Synovial sarcoma of the extremities and trunk
T2 - A long-lasting disease
AU - Gofman, A.
AU - Issakov, J.
AU - Kollender, Y.
AU - Soyfer, V.
AU - Dadia, S.
AU - Jiveliouk, I.
AU - Flusser, G.
AU - Bickels, J.
AU - Meller, I.
AU - Merimsky, Ofer
PY - 2007/12
Y1 - 2007/12
N2 - Synovial sarcoma (SS) of an extremity or trunk is relatively rare and is approached by limb sparing surgery (LSS), radiation therapy (RT) and chemotherapy. We conducted a retrospective analysis of the clinical and histopathological data of 73 patients with proven SS. At a median follow-up time of 6 years, local recurrence was seen in 17.8 and systemic recurrence 35.6% of patients (local-only, 6.8; systemic-only, 24.6; combined, 11%). The 10-year local recurrence-free survival (LRFS), systemic recurrence-free survival (SRFS) and overall survival (OS) rates were 78, 68 and 61%, respectively. LRFS was significantly better in patients treated with isolated limb perfusion (ILP); SRFS was influenced by the delay until diagnosis. The practical aspects of our observations are the need for long-term follow-up in order to diagnose recurrences, the fact that not all local or distant recurrences are necessarily associated with a shortening of OS time and the important role of induction ILP with TNF in cases of extremity SS.
AB - Synovial sarcoma (SS) of an extremity or trunk is relatively rare and is approached by limb sparing surgery (LSS), radiation therapy (RT) and chemotherapy. We conducted a retrospective analysis of the clinical and histopathological data of 73 patients with proven SS. At a median follow-up time of 6 years, local recurrence was seen in 17.8 and systemic recurrence 35.6% of patients (local-only, 6.8; systemic-only, 24.6; combined, 11%). The 10-year local recurrence-free survival (LRFS), systemic recurrence-free survival (SRFS) and overall survival (OS) rates were 78, 68 and 61%, respectively. LRFS was significantly better in patients treated with isolated limb perfusion (ILP); SRFS was influenced by the delay until diagnosis. The practical aspects of our observations are the need for long-term follow-up in order to diagnose recurrences, the fact that not all local or distant recurrences are necessarily associated with a shortening of OS time and the important role of induction ILP with TNF in cases of extremity SS.
KW - Isolated limb perfusion
KW - Radiation therapy
KW - Surgery
KW - Synovial sarcoma
UR - http://www.scopus.com/inward/record.url?scp=38449099444&partnerID=8YFLogxK
U2 - 10.3892/or.18.6.1577
DO - 10.3892/or.18.6.1577
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AN - SCOPUS:38449099444
SN - 1021-335X
VL - 18
SP - 1577
EP - 1581
JO - Oncology Reports
JF - Oncology Reports
IS - 6
ER -
