Synovial sarcoma of the extremities and trunk: A long-lasting disease

A. Gofman, J. Issakov, Y. Kollender, V. Soyfer, S. Dadia, I. Jiveliouk, G. Flusser, J. Bickels, I. Meller, Ofer Merimsky*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Synovial sarcoma (SS) of an extremity or trunk is relatively rare and is approached by limb sparing surgery (LSS), radiation therapy (RT) and chemotherapy. We conducted a retrospective analysis of the clinical and histopathological data of 73 patients with proven SS. At a median follow-up time of 6 years, local recurrence was seen in 17.8 and systemic recurrence 35.6% of patients (local-only, 6.8; systemic-only, 24.6; combined, 11%). The 10-year local recurrence-free survival (LRFS), systemic recurrence-free survival (SRFS) and overall survival (OS) rates were 78, 68 and 61%, respectively. LRFS was significantly better in patients treated with isolated limb perfusion (ILP); SRFS was influenced by the delay until diagnosis. The practical aspects of our observations are the need for long-term follow-up in order to diagnose recurrences, the fact that not all local or distant recurrences are necessarily associated with a shortening of OS time and the important role of induction ILP with TNF in cases of extremity SS.

Original languageEnglish
Pages (from-to)1577-1581
Number of pages5
JournalOncology Reports
Issue number6
StatePublished - Dec 2007


  • Isolated limb perfusion
  • Radiation therapy
  • Surgery
  • Synovial sarcoma


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