TY - JOUR
T1 - Synovial chondromatosis
T2 - The possible role of FGF 9 and FGF receptor 3 in its pathology
AU - Robinson, Dror
AU - Hasharoni, Amir
AU - Evron, Zoharia
AU - Segal, Michael
AU - Nevo, Zvi
PY - 2000
Y1 - 2000
N2 - Primary synovial chondromatosis (PSC) is a rare disorder of the synovium typified by cartilaginous nodule formation within the synovial membrane. Fibroblast growth factor receptor 3 (FGFR3) is a recently described specific marker of mesenchymal precartilaginous stem cells. Expression patterns of FGFR3 and its specific ligand, fibroblast growth factor 9 (FGF 9), were evaluated both in situ and in cell cultures. Histologically, cells at the periphery of the cartilage nodules express FGFR3 and PCNA (proliferating cell nuclear antigen). Elevated levels of FGF 9, its specific ligand, have been found in synovial fluids of patients with synovial chondromatosis. Synoviocytes but not chondrocytes from affected patients express FGF9 in culture. This pattern is absent in normal synovium and cartilage. Downregulation of FGF9 may provide a possible nonoperative therapy for PSC.
AB - Primary synovial chondromatosis (PSC) is a rare disorder of the synovium typified by cartilaginous nodule formation within the synovial membrane. Fibroblast growth factor receptor 3 (FGFR3) is a recently described specific marker of mesenchymal precartilaginous stem cells. Expression patterns of FGFR3 and its specific ligand, fibroblast growth factor 9 (FGF 9), were evaluated both in situ and in cell cultures. Histologically, cells at the periphery of the cartilage nodules express FGFR3 and PCNA (proliferating cell nuclear antigen). Elevated levels of FGF 9, its specific ligand, have been found in synovial fluids of patients with synovial chondromatosis. Synoviocytes but not chondrocytes from affected patients express FGF9 in culture. This pattern is absent in normal synovium and cartilage. Downregulation of FGF9 may provide a possible nonoperative therapy for PSC.
KW - Cartilage
KW - FGF9
KW - FGFR3
KW - Fibroblast growth factor 9
KW - Fibroblast growth factor receptor 3
KW - Mesenchymal cells
KW - Synovia
KW - Synovial chondromatosis
UR - http://www.scopus.com/inward/record.url?scp=0033929955&partnerID=8YFLogxK
U2 - 10.1046/j.1365-2613.2000.00154.x
DO - 10.1046/j.1365-2613.2000.00154.x
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AN - SCOPUS:0033929955
SN - 0959-9673
VL - 81
SP - 183
EP - 189
JO - International Journal of Experimental Pathology
JF - International Journal of Experimental Pathology
IS - 3
ER -