Synergistic effect of N-acetyl-D-glucosamine (NAG) on mitogenic, antigenic and allogeneic stimulation of normal human lymphocytes

Luise Komlos, Shlomo Ben-Efraim, Neil J. Lewis, Jacob Hart, Isaac Halbrecht

Research output: Contribution to journalArticlepeer-review

Abstract

The effect of N-acetyl-D-glucosamine (NAG) on in vitro stimulated human peripheral blood lymphocytes was investigated. NAG was added to lymphocyte cultures stimulated by the mitogen PHA, the antigen PPD or to one-way-stimulated mixed lymphocyte cultures from unrelated donors. The results indicate that NAG (1-2 μg/ml) in appropriate experimental conditions has an enhancing effect on DNA and protein synthesis induced by PHA, PPD and allogeneic cells. Addition of NAG (1-2 μg/ml) to unstimulated lymphocyte cultures had no effect on DNA or protein synthesis.

Original languageEnglish
Pages (from-to)593-599
Number of pages7
JournalInternational Journal of Immunopharmacology
Volume6
Issue number6
DOIs
StatePublished - 1984
Externally publishedYes

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