TY - JOUR
T1 - Synergistic effect of N-acetyl-D-glucosamine (NAG) on mitogenic, antigenic and allogeneic stimulation of normal human lymphocytes
AU - Komlos, Luise
AU - Ben-Efraim, Shlomo
AU - Lewis, Neil J.
AU - Hart, Jacob
AU - Halbrecht, Isaac
PY - 1984
Y1 - 1984
N2 - The effect of N-acetyl-D-glucosamine (NAG) on in vitro stimulated human peripheral blood lymphocytes was investigated. NAG was added to lymphocyte cultures stimulated by the mitogen PHA, the antigen PPD or to one-way-stimulated mixed lymphocyte cultures from unrelated donors. The results indicate that NAG (1-2 μg/ml) in appropriate experimental conditions has an enhancing effect on DNA and protein synthesis induced by PHA, PPD and allogeneic cells. Addition of NAG (1-2 μg/ml) to unstimulated lymphocyte cultures had no effect on DNA or protein synthesis.
AB - The effect of N-acetyl-D-glucosamine (NAG) on in vitro stimulated human peripheral blood lymphocytes was investigated. NAG was added to lymphocyte cultures stimulated by the mitogen PHA, the antigen PPD or to one-way-stimulated mixed lymphocyte cultures from unrelated donors. The results indicate that NAG (1-2 μg/ml) in appropriate experimental conditions has an enhancing effect on DNA and protein synthesis induced by PHA, PPD and allogeneic cells. Addition of NAG (1-2 μg/ml) to unstimulated lymphocyte cultures had no effect on DNA or protein synthesis.
UR - http://www.scopus.com/inward/record.url?scp=0021707442&partnerID=8YFLogxK
U2 - 10.1016/0192-0561(84)90070-5
DO - 10.1016/0192-0561(84)90070-5
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AN - SCOPUS:0021707442
VL - 6
SP - 593
EP - 599
JO - International Immunopharmacology
JF - International Immunopharmacology
SN - 1567-5769
IS - 6
ER -