Synergism between cytotoxin P4 from the snake venom of Naja nigricollis nigricollis and various phospholipases

Adina Chaim-Matyas, Gadi Borkow, Michael Ovadia

Research output: Contribution to journalArticlepeer-review

Abstract

The synergism between the lytic activity of cytotoxin P4 isolated from the venom of Naja nigricollis nigricollis and various phospholipases (PLA) is demonstrated. The highest synergistic activity was obtained with one of the basic phospholipases found in the same venom. It was also shown between cytotoxin P4 and heterologous elapid and viperid snake phospholipases. Moreover, remarkable synergism was also demonstrated between cytotoxin P4 and bee venom PLA2 or porcine pancreatic PLA2. However, the phospholipase fractions of Vipera palestinae and the bovine pancreas PLA2 had no synergistic effect.

Original languageEnglish
Pages (from-to)83-89
Number of pages7
JournalComparative Biochemistry and Physiology - B Biochemistry and Molecular Biology
Volume110
Issue number1
DOIs
StatePublished - Jan 1995

Keywords

  • Cytotoxin
  • Phospholipase A
  • Snake venom
  • Synergism

Fingerprint

Dive into the research topics of 'Synergism between cytotoxin P4 from the snake venom of Naja nigricollis nigricollis and various phospholipases'. Together they form a unique fingerprint.

Cite this