Synergism between cytotoxin P4 from the snake venom of Naja nigricollis nigricollis and various phospholipases

Adina Chaim-Matyas; Gadi Borkow; Michael Ovadia

doi:10.1016/0305-0491(94)00130-M

Synergism between cytotoxin P4 from the snake venom of Naja nigricollis nigricollis and various phospholipases

Adina Chaim-Matyas, Gadi Borkow, Michael Ovadia^*

^*Corresponding author for this work

School of Zoology

Tel Aviv University

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

The synergism between the lytic activity of cytotoxin P4 isolated from the venom of Naja nigricollis nigricollis and various phospholipases (PLA) is demonstrated. The highest synergistic activity was obtained with one of the basic phospholipases found in the same venom. It was also shown between cytotoxin P4 and heterologous elapid and viperid snake phospholipases. Moreover, remarkable synergism was also demonstrated between cytotoxin P4 and bee venom PLA₂ or porcine pancreatic PLA₂. However, the phospholipase fractions of Vipera palestinae and the bovine pancreas PLA₂ had no synergistic effect.

Original language	English
Pages (from-to)	83-89
Number of pages	7
Journal	Comparative Biochemistry and Physiology Part - B: Biochemistry and Molecular Biology
Volume	110
Issue number	1
DOIs	https://doi.org/10.1016/0305-0491(94)00130-M
State	Published - Jan 1995

Keywords

Cytotoxin
Phospholipase A
Snake venom
Synergism

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abstract = "The synergism between the lytic activity of cytotoxin P4 isolated from the venom of Naja nigricollis nigricollis and various phospholipases (PLA) is demonstrated. The highest synergistic activity was obtained with one of the basic phospholipases found in the same venom. It was also shown between cytotoxin P4 and heterologous elapid and viperid snake phospholipases. Moreover, remarkable synergism was also demonstrated between cytotoxin P4 and bee venom PLA2 or porcine pancreatic PLA2. However, the phospholipase fractions of Vipera palestinae and the bovine pancreas PLA2 had no synergistic effect.",

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AU - Borkow, Gadi

AU - Ovadia, Michael

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N2 - The synergism between the lytic activity of cytotoxin P4 isolated from the venom of Naja nigricollis nigricollis and various phospholipases (PLA) is demonstrated. The highest synergistic activity was obtained with one of the basic phospholipases found in the same venom. It was also shown between cytotoxin P4 and heterologous elapid and viperid snake phospholipases. Moreover, remarkable synergism was also demonstrated between cytotoxin P4 and bee venom PLA2 or porcine pancreatic PLA2. However, the phospholipase fractions of Vipera palestinae and the bovine pancreas PLA2 had no synergistic effect.

AB - The synergism between the lytic activity of cytotoxin P4 isolated from the venom of Naja nigricollis nigricollis and various phospholipases (PLA) is demonstrated. The highest synergistic activity was obtained with one of the basic phospholipases found in the same venom. It was also shown between cytotoxin P4 and heterologous elapid and viperid snake phospholipases. Moreover, remarkable synergism was also demonstrated between cytotoxin P4 and bee venom PLA2 or porcine pancreatic PLA2. However, the phospholipase fractions of Vipera palestinae and the bovine pancreas PLA2 had no synergistic effect.

KW - Cytotoxin

KW - Phospholipase A

KW - Snake venom

KW - Synergism

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Synergism between cytotoxin P4 from the snake venom of Naja nigricollis nigricollis and various phospholipases

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