Syndecan 1 (CD138) serum levels: A novel biomarker in predicting liver fibrosis stage in patients with hepatitis C

Isabel Zvibel, Phillipe Halfon, Sigal Fishman, Guillaume Penaranda, Moshe Leshno, Anat Bet Or, Zamir Halpern, Ran Oren

Research output: Contribution to journalArticlepeer-review

Abstract

Background and Aims: Syndecan 1 (CD 138) is a cell surface proteoglycan shed by cells in several pathological conditions, including wound healing. The aim of this study was to test whether CD138 could serve as a non-invasive marker for detection of liver fibrosis and thereby reduce the need for liver biopsy. Patients and Methods: An estimation set of 134 patients and a validation set of 67 patients with chronic hepatitis C were studied. There were 80 normal healthy volunteers. Patients were staged according to liver biopsies (Metavir fibrosis staging, stage F0, n = 35; F1, n = 40; F2, n = 37, F3, n = 39; F4, n = 51). Serum CD138 levels were retrospectively measured by enzyme-linked immunoabsorbent assay the same day of the liver biopsy. The primary endpoints were the diagnostic values of CD138 for F2-F4, F3-F4 and F4. Results: Respective areas under receiver operating characteristic curve of CD138 for F2-F4, F3-F4 and F4 diagnosis were 0.82, 0.76 and 0.81. CD138 had a positive predictive value of 82% for F2-F4 diagnosis and a high negative predictive value (86%) and specificity (84%) for exclusion of F4. Conclusion: CD138 is a new simple non-invasive marker for predicting liver fibrosis in patients with chronic hepatitis C. The relevance of this marker in combination with other fibrosis markers should be explored.

Original languageEnglish
Pages (from-to)208-212
Number of pages5
JournalLiver International
Volume29
Issue number2
DOIs
StatePublished - 2009

Keywords

  • Hepatitis C
  • Liverf ibrosis
  • Syndecan 1

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