Syncytial giant-cell hepatitis due to autoimmune hepatitis type II (LKM1 +) presenting as subfulminant hepatitis

Ziv Ben-Ari*, Effrat Broida, Yehudit Monselise, Anna Kazatsker, Jacob Baruch, Orit Pappo, Eitan Skappa, Ran Tur-Kaspa

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Giant cell hepatitis (GCH) in adults is a rare event. The diagnosis of GCH is based on findings of syncytial giant hepatocytes. It is commonly associated with either viral infection or autoimmune hepatitis type I. A patient with GCH due to autoimmune hepatitis type II (LKM1+) is described, a combination that has not been previously reported. Corticosteroid therapy was effective in decreasing serum liver enzymes; however, the patient deteriorated rapidly and developed subfulminant hepatic failure. Although an emergency orthotopic liver transplantation was performed, the patient died because of reperfusion injury. Interestingly, only a few giant hepatocytes were noted in the explanted liver. This case stresses the association of GCH with autoimmune disorders, the possible immune mechanism involved in the formation of giant cell hepatocytes, and illustrates the rapidly progressive course and unfavorable prognosis that these patients can develop. (C) 2000 by Am. Coll. of Gastroenterology.

Original languageEnglish
Pages (from-to)799-801
Number of pages3
JournalAmerican Journal of Gastroenterology
Volume95
Issue number3
DOIs
StatePublished - Mar 2000

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