Syncope in primary prevention implantable cardioverter defibrillator implantation

Gustavo Goldenberg, Tamir Bental, Udi Kadmon, Ronit Zabarsky, Jairo Kusnick, Alon Barsheshet, Gregory Golovchiner, Boris Strasberg

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Syncope prognosis varies widely: 1 year mortality may range from 0% in the case of vasovagal events up to 30% in the presence of heart disease. Objectives: To assess the outcomes and prognosis of patients with implantable cardiac defibrillator (ICD) and indication of primary prevention and compare patients presenting with or without prior syncope. Methods: We reviewed the charts of 75 patients who underwent ICD implantation with the indication of primary prevention and history of syncope and compared them to a control group of 80 patients without prior syncope. We assessed the number of episodes of ventricular tachycardia (VT), ventricular fibrillation (VF), shock, anti-tachycardia pacing (ATP), and death in each group during the follow-up. Results: Mean follow-up was 893 days (810–976, 95% confidence interval) (no difference between groups). Patients with prior syncope had a higher ejection fraction (EF) (35.5 ± 12.6 vs. 31.4 ± 8.76, P = 0.02), more episodes of VT (21.3% vs. 3.8%, P = 0.001) and VF (8% vs. 0%, P = 0.01) and also received more electric shocks (18.7% vs. 3.8%, P = 0.004) and ATP (17.3% vs. 6.2%, P = 0.031). There were no differences in inappropriate shocks (6.7% vs. 5%, P = 0.74), in cardiovascular mortality (cumulative 5 year estimate 29.9% vs. 32.2% P = 0.97) and any death (cumulative 5 year estimate 38.1% vs. 48.9% P = 0.18) during the follow-up. Conclusions: Syncopal patients before ICD implantation seem to have more episodes of VT/VF and shock or ATP. No mortality differences were observed.

Original languageEnglish
Pages (from-to)15-18
Number of pages4
JournalIsrael Medical Association Journal
Volume19
Issue number1
StatePublished - Jan 2017

Keywords

  • Implantable cardiac defibrillator (ICD)
  • Sudden death
  • Syncope
  • Ventricular fibrillation (VF)
  • Ventricular tachycardia (VT)

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