@article{ec60c41575974936bfa3dd696261461c,
title = "Synaptojanin 2 is a druggable mediator of metastasis and the gene is overexpressed and amplified in breast cancer",
abstract = "Amplified HER2, which encodes a member of the epidermal growth factor receptor (EGFR) family, is a target of effective therapies against breast cancer. In search for similarly targetable genomic aberrations, we identified copy number gains in SYNJ2, which encodes the 5′-inositol lipid phosphatase synaptojanin 2, as well as overexpression in a small fraction of human breast tumors. Copy gain and overexpression correlated with shorter patient survival and a low abundance of the tumor suppressor microRNA miR-31. SYNJ2 promoted cell migration and invasion in culture and lung metastasis of breast tumor xenografts in mice. Knocking down SYNJ2 impaired the endocytic recycling of EGFR and the formation of cellular lamellipodia and invadopodia. Screening compound libraries identified SYNJ2-specific inhibitors that prevented cell migration but did not affect the related neural protein SYNJ1, suggesting that SYNJ2 is a potentially druggable target to block cancer cell migration.",
author = "Nir Ben-Chetrit and David Chetrit and Roslin Russell and Cindy K{\"o}rner and Maicol Mancini and Ali Abdul-Hai and Tomer Itkin and Silvia Carvalho and Hadas Cohen-Dvashi and Koestler, {Wolfgang J.} and Kirti Shukla and Moshit Lindzen and Merav Kedmi and Mattia Lauriola and Ziv Shulman and Haim Barr and Dalia Seger and Ferraro, {Daniela A.} and Fresia Pareja and Hava Gil-Henn and Tsvee Lapidot and Ronen Alon and Ferna Milanezi and Marc Symons and Rotem Ben-Hamo and Sol Efroni and Ferno Schmitt and Stefan Wiemann and Carlos Caldas and Marcelo Ehrlich and Yosef Yarden",
note = "Publisher Copyright: {\textcopyright} 2015, American Association for the Advancement of Science. All rights reserved.",
year = "2015",
month = jan,
day = "20",
doi = "10.1126/scisignal.2005537",
language = "אנגלית",
volume = "8",
journal = "Science Signaling",
issn = "1945-0877",
publisher = "American Association for the Advancement of Science",
number = "360",
}