Synaptic frequency response: the influence of sinusoidal changes in stimulation frequency on the amplitude of the end‐plate potential

E. M. Landau*, Y. Lass

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

1. The synaptic response to frequency modulated trains of stimuli was investigated at the neuromuscular junction of the frog. The frequency of stimulation was usually varied sinusoidally about a carrier frequency of ca. 25 impulses per sec (Hz). 2. The post‐synaptic response to sinusoidally modulated trains of nerve stimuli was found to grow almost linearly when the variations in input frequency were increased up to 60% of the carrier frequency. 3. The synaptic frequency response (gain and phase) was reminiscent of that of a low‐pass filter, best transmitting slow variations in input frequency. 4. The synaptic filter characteristics could not be explained by the post‐synaptic cable properties, but were attributed to presynaptic facilitation processes.

Original languageEnglish
Pages (from-to)27-40
Number of pages14
JournalJournal of Physiology
Volume228
Issue number1
DOIs
StatePublished - 1 Jan 1973

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