TY - JOUR
T1 - Symptomatic corpus luteum hemorrhage in adolescent females with ITP
AU - Yelak, Alexander
AU - From, Anat
AU - Gilad, Oded
AU - Brik Simon, Dafna
AU - Rubin, Shiri
AU - Cohen, Miriam
AU - Amarilyo, Gil
AU - Levin, Carina
AU - Bakry, Doua
AU - Izraeli, Shai
AU - Tamary, Hannah
AU - Yacobovich, Joanne
AU - Steinberg-Shemer, Orna
N1 - Publisher Copyright:
© The Author(s) 2024.
PY - 2024/7
Y1 - 2024/7
N2 - Patients with immune thrombocytopenia (ITP) usually present with minor mucocutaneous bleeding. Corpus luteum hemorrhage (CLH) is generally asymptomatic but may, rarely, lead to severe intraperitoneal bleeding, mostly in patients with coagulation disorders. CLH causing intraperitoneal bleeding has only been described in few individuals with ITP. The objective of this retrospective observational study was to assess the clinical course and incidence of symptomatic CLH in adolescent females with newly diagnosed or chronic ITP. Additionally, a comprehensive literature review was conducted to scrutinize cases of pediatric female patients with ITP, complicated by CLH. We identified three patients with ITP and hemoperitoneum secondary to CLH. They presented with acute abdominal pain, had severe thrombocytopenia (platelet counts below 20 × 109/L), and required blood transfusions as well as ITP-directed therapy. All the patients were hemodynamically stable and did not require emergency surgical intervention. Conclusion: CLH could potentially pose a significant complication in the context of adolescent females with ITP, requiring a strong index of suspicion to direct expedient therapy. (Table presented.)
AB - Patients with immune thrombocytopenia (ITP) usually present with minor mucocutaneous bleeding. Corpus luteum hemorrhage (CLH) is generally asymptomatic but may, rarely, lead to severe intraperitoneal bleeding, mostly in patients with coagulation disorders. CLH causing intraperitoneal bleeding has only been described in few individuals with ITP. The objective of this retrospective observational study was to assess the clinical course and incidence of symptomatic CLH in adolescent females with newly diagnosed or chronic ITP. Additionally, a comprehensive literature review was conducted to scrutinize cases of pediatric female patients with ITP, complicated by CLH. We identified three patients with ITP and hemoperitoneum secondary to CLH. They presented with acute abdominal pain, had severe thrombocytopenia (platelet counts below 20 × 109/L), and required blood transfusions as well as ITP-directed therapy. All the patients were hemodynamically stable and did not require emergency surgical intervention. Conclusion: CLH could potentially pose a significant complication in the context of adolescent females with ITP, requiring a strong index of suspicion to direct expedient therapy. (Table presented.)
KW - Bleeding
KW - Corpus luteum hemorrhage
KW - ITP
KW - Thrombocytopenia
UR - http://www.scopus.com/inward/record.url?scp=85189971023&partnerID=8YFLogxK
U2 - 10.1007/s00431-024-05560-0
DO - 10.1007/s00431-024-05560-0
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C2 - 38602530
AN - SCOPUS:85189971023
SN - 0340-6199
VL - 183
SP - 2893
EP - 2897
JO - European Journal of Pediatrics
JF - European Journal of Pediatrics
IS - 7
ER -