Symptomatic corpus luteum hemorrhage in adolescent females with ITP

Alexander Yelak, Anat From, Oded Gilad, Dafna Brik Simon, Shiri Rubin, Miriam Cohen, Gil Amarilyo, Carina Levin, Doua Bakry, Shai Izraeli, Hannah Tamary, Joanne Yacobovich, Orna Steinberg-Shemer*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Patients with immune thrombocytopenia (ITP) usually present with minor mucocutaneous bleeding. Corpus luteum hemorrhage (CLH) is generally asymptomatic but may, rarely, lead to severe intraperitoneal bleeding, mostly in patients with coagulation disorders. CLH causing intraperitoneal bleeding has only been described in few individuals with ITP. The objective of this retrospective observational study was to assess the clinical course and incidence of symptomatic CLH in adolescent females with newly diagnosed or chronic ITP. Additionally, a comprehensive literature review was conducted to scrutinize cases of pediatric female patients with ITP, complicated by CLH. We identified three patients with ITP and hemoperitoneum secondary to CLH. They presented with acute abdominal pain, had severe thrombocytopenia (platelet counts below 20 × 109/L), and required blood transfusions as well as ITP-directed therapy. All the patients were hemodynamically stable and did not require emergency surgical intervention. Conclusion: CLH could potentially pose a significant complication in the context of adolescent females with ITP, requiring a strong index of suspicion to direct expedient therapy. (Table presented.)

Original languageEnglish
Pages (from-to)2893-2897
Number of pages5
JournalEuropean Journal of Pediatrics
Issue number7
StatePublished - Jul 2024


  • Bleeding
  • Corpus luteum hemorrhage
  • ITP
  • Thrombocytopenia


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