Switchable motion of DNA on solid supports

Johann Elbaz, Ran Tel-Vered, Ronit Freeman, Huseyin Bekir Yildiz, Itamar Willner

Research output: Contribution to journalArticlepeer-review

Abstract

Tracking the changes: The switchable translocation of a nucleic acid strand with a methylene blue (MB+) redox group on a DNA track associated with a surface can be triggered by adenosine monophosphate (AMP, green) and adenosine deaminase (purple, see picture); the latter converts AMP into inosine monophosphate (orange). The motion of the nucleic acid can be followed by the electrochemical, photo-electrochemical, and fluorescence signals. (Figure Presented).

Original languageEnglish
Pages (from-to)133-137
Number of pages5
JournalAngewandte Chemie - International Edition
Volume48
Issue number1
DOIs
StatePublished - 2009
Externally publishedYes

Keywords

  • Aptamers
  • DNA
  • FRET
  • Molecular devices
  • Nanoparticles

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