Survival after intervention in patients with low gradient severe aortic stenosis and preserved left ventricular function

Avishay Grupper; Roy Beigel; Elad Maor; Rafael Kuperstein; Ilan Hai; Olga Perelshtein; Ilan Goldenberg; Micha Feinberg; Sagit Ben Zekry

doi:10.1016/j.jtcvs.2014.03.039

Survival after intervention in patients with low gradient severe aortic stenosis and preserved left ventricular function

Avishay Grupper, Roy Beigel, Elad Maor, Rafael Kuperstein, Ilan Hai, Olga Perelshtein, Ilan Goldenberg, Micha Feinberg, Sagit Ben Zekry^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Objective The outcome of aortic valve replacement for patients with low gradient severe aortic stenosis and preserved ejection fraction has been debated. The aim of the present study was to evaluate the effect of aortic valve intervention on survival in that group.

Results During an average follow-up of 28 months, of 416 study patients (mean age, 76 ± 14 years, 42% men), 97 (23%) underwent aortic valve intervention and 140 (32%) died. Mantel-Byar analysis showed that the cumulative probability of survival was significantly greater after aortic valve intervention. Multivariate analysis revealed a 49% reduction in the risk of death after surgery (P <.05). The survival benefit of aortic valve intervention was comparable with adjustment to older age, aortic valve area ≤ 0.8 cm², and a low (≤35cm²/m²) or normal (>35 cm²/m²) stroke volume index.

Conclusions Our findings suggest that aortic valve intervention is associated with improved survival among patients with low gradient severe aortic stenosis and preserved left ventricular function. The presence of either a low or normal stroke volume index did not affect the mortality benefit.

Original language	English
Pages (from-to)	2823-2828
Number of pages	6
Journal	Journal of Thoracic and Cardiovascular Surgery
Volume	148
Issue number	6
DOIs	https://doi.org/10.1016/j.jtcvs.2014.03.039
State	Published - 1 Dec 2014

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.jtcvs.2014.03.039

Cite this

@article{f676f96ce7984c61a0a90f96fb21cef7,

title = "Survival after intervention in patients with low gradient severe aortic stenosis and preserved left ventricular function",

abstract = "Objective The outcome of aortic valve replacement for patients with low gradient severe aortic stenosis and preserved ejection fraction has been debated. The aim of the present study was to evaluate the effect of aortic valve intervention on survival in that group.Results During an average follow-up of 28 months, of 416 study patients (mean age, 76 ± 14 years, 42% men), 97 (23%) underwent aortic valve intervention and 140 (32%) died. Mantel-Byar analysis showed that the cumulative probability of survival was significantly greater after aortic valve intervention. Multivariate analysis revealed a 49% reduction in the risk of death after surgery (P <.05). The survival benefit of aortic valve intervention was comparable with adjustment to older age, aortic valve area ≤ 0.8 cm2, and a low (≤35cm2/m2) or normal (>35 cm2/m2) stroke volume index.Conclusions Our findings suggest that aortic valve intervention is associated with improved survival among patients with low gradient severe aortic stenosis and preserved left ventricular function. The presence of either a low or normal stroke volume index did not affect the mortality benefit.",

author = "Avishay Grupper and Roy Beigel and Elad Maor and Rafael Kuperstein and Ilan Hai and Olga Perelshtein and Ilan Goldenberg and Micha Feinberg and {Ben Zekry}, Sagit",

year = "2014",

month = dec,

day = "1",

doi = "10.1016/j.jtcvs.2014.03.039",

language = "אנגלית",

volume = "148",

pages = "2823--2828",

journal = "Journal of Thoracic and Cardiovascular Surgery",

issn = "0022-5223",

publisher = "Elsevier Inc.",

number = "6",

}

TY - JOUR

T1 - Survival after intervention in patients with low gradient severe aortic stenosis and preserved left ventricular function

AU - Grupper, Avishay

AU - Beigel, Roy

AU - Maor, Elad

AU - Kuperstein, Rafael

AU - Hai, Ilan

AU - Perelshtein, Olga

AU - Goldenberg, Ilan

AU - Feinberg, Micha

AU - Ben Zekry, Sagit

PY - 2014/12/1

Y1 - 2014/12/1

N2 - Objective The outcome of aortic valve replacement for patients with low gradient severe aortic stenosis and preserved ejection fraction has been debated. The aim of the present study was to evaluate the effect of aortic valve intervention on survival in that group.Results During an average follow-up of 28 months, of 416 study patients (mean age, 76 ± 14 years, 42% men), 97 (23%) underwent aortic valve intervention and 140 (32%) died. Mantel-Byar analysis showed that the cumulative probability of survival was significantly greater after aortic valve intervention. Multivariate analysis revealed a 49% reduction in the risk of death after surgery (P <.05). The survival benefit of aortic valve intervention was comparable with adjustment to older age, aortic valve area ≤ 0.8 cm2, and a low (≤35cm2/m2) or normal (>35 cm2/m2) stroke volume index.Conclusions Our findings suggest that aortic valve intervention is associated with improved survival among patients with low gradient severe aortic stenosis and preserved left ventricular function. The presence of either a low or normal stroke volume index did not affect the mortality benefit.

AB - Objective The outcome of aortic valve replacement for patients with low gradient severe aortic stenosis and preserved ejection fraction has been debated. The aim of the present study was to evaluate the effect of aortic valve intervention on survival in that group.Results During an average follow-up of 28 months, of 416 study patients (mean age, 76 ± 14 years, 42% men), 97 (23%) underwent aortic valve intervention and 140 (32%) died. Mantel-Byar analysis showed that the cumulative probability of survival was significantly greater after aortic valve intervention. Multivariate analysis revealed a 49% reduction in the risk of death after surgery (P <.05). The survival benefit of aortic valve intervention was comparable with adjustment to older age, aortic valve area ≤ 0.8 cm2, and a low (≤35cm2/m2) or normal (>35 cm2/m2) stroke volume index.Conclusions Our findings suggest that aortic valve intervention is associated with improved survival among patients with low gradient severe aortic stenosis and preserved left ventricular function. The presence of either a low or normal stroke volume index did not affect the mortality benefit.

UR - http://www.scopus.com/inward/record.url?scp=84920196281&partnerID=8YFLogxK

U2 - 10.1016/j.jtcvs.2014.03.039

DO - 10.1016/j.jtcvs.2014.03.039

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???

C2 - 24787695

AN - SCOPUS:84920196281

SN - 0022-5223

VL - 148

SP - 2823

EP - 2828

JO - Journal of Thoracic and Cardiovascular Surgery

JF - Journal of Thoracic and Cardiovascular Surgery

IS - 6

ER -

Survival after intervention in patients with low gradient severe aortic stenosis and preserved left ventricular function

Abstract

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this