Surgical site infections following craniotomy focusing on possible post-operative acquisition of infection: Prospective cohort study

O. Sneh-Arbib, A. Shiferstein, N. Dagan, S. Fein, L. Telem, E. Muchtar, N. Eliakim-Raz, B. Rubinovitch, G. Rubin, Z. H. Rappaport, M. Paul

Research output: Contribution to journalArticlepeer-review

Abstract

Neurosurgery is characterized by a prolonged risk period for surgical site infection (SSI), mainly related to the presence of cerebrospinal fluid (CSF) drains. We aimed to examine factors associated with post-neurosurgical SSIs, focusing on post-operative factors. A prospective cohort study was conducted in a single center over a period of 18 months in Israel. Included were adult patients undergoing clean or clean-contaminated craniotomy, including craniotomies with external CSF drainage or shunts. SSIs were defined by the Centers for Disease Control and Prevention (CDC) criteria for healthcare-associated infections. All patients were followed up for 90 days and those with foreign body insertion for 1 year. We compared patients with and without SSI. A multivariable regression analysis for SSI was conducted including uncorrelated variables significantly associated with SSI. A total of 502 patients were included, with 138 (27.5 %) undergoing emergent or urgent craniotomy. The overall SSI rate was 5.6 % (28 patients), of which 3.2 % (16 patients) were intracerebral. Non-elective surgery, external CSF drainage/monitoring devices, re-operation, and post-operative respiratory failure were independently associated with subsequent SSI. External CSF devices was the only significant risk factor for intracerebral SSIs (p < 0.001). Internal shunts or other foreign body insertions were not associated with SSIs. A phenotypically identical isolate to that causing the SSI was isolated from respiratory secretions prior to the SSI in 4/9 patients with microbiologically documented intracerebral SSIs. Patients with SSIs had longer hospital stay, poorer functional capacity on discharge, and higher 90-day mortality. We raise the possibility of post-operative infection acquisition through external CSF devices. Standard operating procedures for their maintenance are necessary.

Original languageEnglish
Pages (from-to)1511-1516
Number of pages6
JournalEuropean Journal of Clinical Microbiology and Infectious Diseases
Volume32
Issue number12
DOIs
StatePublished - Dec 2013

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