Surgical approaches for infratemporal fossa tumor resection: Fifteen years' experience of a single center

Daniel Yafit, Irit Duek, Sara Abu-Ghanem, Omer J. Ungar, Anat Wengier, Helena Moshe-Levyn, Ravit Yanko-Arzi, Arik Zaretski, Nevo Margalit, Avraham Abergel, Nidal Muhanna, Dan M. Fliss

Research output: Contribution to journalArticlepeer-review


Background: The aims of this study were to report our center's experience with infratemporal fossa (ITF) tumors, to review the treatment modalities and outcomes. Methods: Data of patients that underwent resection of ITF tumors in a single tertiary referral medical center were collected and analyzed. Results: Sixty-three patients were included. Sarcoma was the most common pathology (18; 29%). The most common surgical approach was the preauricular-orbitozygomatic approach (24; 38%), followed by endoscopic, craniofacial resection, and combined approaches. Forty-seven patients (75%) required reconstruction, 23 (49%) involving free tissue transfer. Thirty-five patients (76%) with malignant lesions required adjuvant therapy consisting of radiotherapy, chemotherapy, or both. Thirty-three patients suffered from complications related to surgery or adjuvant therapy. The three- and five-years survival rates for malignancy were 82% and 66%, respectively. Conclusion: Complete surgical resection of ITF involving tumors is feasible, providing good long-term survival. Multidisciplinary approach is the key for success.

Original languageEnglish
Pages (from-to)3755-3763
Number of pages9
JournalHead and Neck
Issue number11
StatePublished - 1 Nov 2019


  • fronto-orbitozygomatic approach
  • infratemporal fossa
  • skull base


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