Surface features of Sezary cells. A scanning electron microscopy study

The surface features of circulating cells from three patients with Sezary syndrome were examined by scanning electron microscopy. The Sezary cells were mostly spherical and displayed varying numbers of microvilli. Most cells had moderately to markedly villous surfaces and had surface features similar to circulating leukemic lymphocytes isolated from patients with chronic lymphocytic leukemia. Some cells were more irregular in shape, while others displayed clusters of polarized microvilli and small uropods. Similar findings were seen in thin sections of cells on transmission electron microscopy.