Suppressive Effect of Pregnancy on the Development of Experimental Allergic Encephalomyelitis in Rabbits

SHMUEL EVRON, TALMA BRENNER, ODED ABRAMSKY

Research output: Contribution to journalArticlepeer-review

Abstract

ABSTRACT: In the present study we have investigated the influence of pregnancy on the induction and development of experimental autoimmune encephalomyelitis (EAE) in rabbits in relation to the time of gestation. Randomly bred rabbits were immunized with encephalitogenic bovine brain homogenate in complete Freund's adjuvant before or during pregnancy. The appearance of EAE was delayed and occurred only after delivery, abortion, or fetal resorption. The incidence of the disease was lower and the duration longer. The levels of antibodies to myelin basic protein, an autoantigen of EAE, as measured by solid phase radioimmunoassay, were lower in the pregnant rabbits as compared to the nonpregnant animals. The suppressive influence of pregnancy on the induction and the development of EAE confirms previous reports demonstrating amelioration of autoimmune diseases and other immunological reactions during the second half of human pregnancy. This effect might be partially attributed to the increased level of alpha‐fetoprotein (AFP) and/or other pregnancy‐associated factors in maternal serum. 1984 Munksgaard

Original languageEnglish
Pages (from-to)109-113
Number of pages5
JournalAmerican Journal of Reproductive Immunology
Volume5
Issue number3
DOIs
StatePublished - 1984
Externally publishedYes

Keywords

  • Experimental allergic encephalomyelitis
  • immunosuppression
  • myelin basic protein antibody
  • pregnancy

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