Suppression of serum gonadal steroids in rats by chronic treatment with dopamine and serotonin reuptake inhibitors

Moshe Rehavi*, Gitit Attali, Irit Gil-Ad, Abraham Weizman

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

The impact of chronic administration (3 weeks) of dopamine and serotonin reuptake inhibitors on serum gonadal steroid hormones and prolactin was studied in intact male and female rats. Both the dopamine and the serotonin reuptake inhibitors lowered serum estradiol and progesterone levels in the female rats. The dopamine transporter blockers suppressed testosterone serum levels in the male rats, whereas serotonin reuptake inhibitors induced only a non-significant reduction (30%) of this hormone. In contrast to the decrease in gonadal steroids, none of the serotonin or the dopamine reuptake blockers altered prolactin serum levels in either the male or female rats. It seems that the effect of these agents on ovarian and testicular hormones is related to the impact of the monoamine reuptake inhibitors on the hypothalamic- pituitary-gonadal axis. (C) 2000 Elsevier Science B.V.

Original languageEnglish
Pages (from-to)145-150
Number of pages6
JournalEuropean Neuropsychopharmacology
Volume10
Issue number3
DOIs
StatePublished - May 2000

Funding

FundersFunder number
Ministry of Health, State of Israel

    Keywords

    • Dopamine transporter
    • Estradiol
    • Gonadal hormones
    • Progesterone
    • Prolactin
    • Serotonin transporter
    • Testosterone

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