Suppression of immune response to sheep red blood cells in mice treated with preparations of a tumor cell component and in tumor‐bearing mice

Mary A. Pikovski*, Y. Ziffroni‐Gallon, I. P. Witz

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

The frequency of rosette‐forming cells (RFC) in spleens of mice immunized with sheep red blood cells (SRBC) was significantly reduced by pretreatment with preparations obtained from tumor extracts. This effect was not produced by preparations obtained by similar methods from normal tissue extracts. Significant suppression of RFC frequency was also found in spleens of mice immunized with SRBC at late stages of tumor growth, as compared to that in immunized controls and in mice bearing tumors at early stages. The results suggest that at late stages, a tumor cell component is released by tumor cells which may be similar to the nondialyzable immune suppressive factor(s) separated by us from tumor extracts, factors found in ascites fluid of tumor‐bearing mice and those known to be released from tumor cells in vitro.

Original languageEnglish
Pages (from-to)447-450
Number of pages4
JournalEuropean Journal of Immunology
Volume5
Issue number7
DOIs
StatePublished - Jul 1975

Fingerprint

Dive into the research topics of 'Suppression of immune response to sheep red blood cells in mice treated with preparations of a tumor cell component and in tumor‐bearing mice'. Together they form a unique fingerprint.

Cite this