Suppression of human metapneumovirus (HMPV) infection by the innate sensing gene CEACAM1

Mohammad Diab, Alon Vitenshtein, Yaron Drori, Rachel Yamin, Oded Danziger, Rachel Zamostiano, Michal Mandelboim, Eran Bacharach, Ofer Mandelboim

Research output: Contribution to journalArticlepeer-review

Abstract

The innate sensing system is equipped with PRRs specialized in recognizing molecular structures (PAMPs) of various pathogens. This leads to the induction of anti-viral genes and inhibition of virus growth. Human Metapneumovirus (HMPV) is a major respiratory virus that causes an upper and lower respiratory tract infection in children. In this study we show that upon HMPV infection, the innate sensing system detects the viral RNA through the RIG-I sensor leading to induction of CEACAM1 expression. We further show that CEACAM1 is induced via binding of IRF3 to the CEACAM1 promoter. We demonstrate that induction of CEACAM1 suppresses the viral loads via inhibition of the translation machinery in the infected cells in an SHP2- dependent manner. In summary, we show here that HMPV-infected cells upregulates CEACAM1 to restrict HMPV infection.

Original languageEnglish
Pages (from-to)66468-66479
Number of pages12
JournalOncotarget
Volume7
Issue number41
DOIs
StatePublished - 2016

Keywords

  • CEACAM1
  • HMPV
  • Immune response
  • Immunity
  • Immunology and Microbiology Section
  • PAMPs
  • PRRs
  • RIG-I
  • RLRs
  • SHP2

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