TY - JOUR
T1 - Suppression of gastric acid secretion by furosemide in isolated gastric mucosa of guinea pig
AU - Ayalon, A.
AU - Corcia, A.
AU - Klemperer, G.
AU - Caplan, S. R.
PY - 1980
Y1 - 1980
N2 - The effect of furosemide on acid secretion and Cl- transport was studied in isolated fundic mucosa of the guinea pig. Furosemide (10-3 M), applied to the serosal side produced an immediate effect on the short-circuit current (I(sc)), lowering it by 47 ± 2%. Potential difference decreased by 29 ± 3%, electrical conductance by 18 ± 4%, acid secretion by 38 ± 1%, and net flux of Cl- from serosal-to-mucosal side by 37%. Application of the drug to the mucosal side produced similar effects on acid secretion and on the electrical parameters. It is suggested that furosemide blocks the entrance of Cl-, by the Na+ - Cl- cotransport mechanism, through the basolateral membrane of the secreting cell. The consequent reduction in electrogenic Cl- transport would cause I(sc) and acid secretion to decrease. A reduction of Cl- conductance of the apical membrane, upon mucosal application of the drug, would cause similar effects on acid secretion and Cl- transport.
AB - The effect of furosemide on acid secretion and Cl- transport was studied in isolated fundic mucosa of the guinea pig. Furosemide (10-3 M), applied to the serosal side produced an immediate effect on the short-circuit current (I(sc)), lowering it by 47 ± 2%. Potential difference decreased by 29 ± 3%, electrical conductance by 18 ± 4%, acid secretion by 38 ± 1%, and net flux of Cl- from serosal-to-mucosal side by 37%. Application of the drug to the mucosal side produced similar effects on acid secretion and on the electrical parameters. It is suggested that furosemide blocks the entrance of Cl-, by the Na+ - Cl- cotransport mechanism, through the basolateral membrane of the secreting cell. The consequent reduction in electrogenic Cl- transport would cause I(sc) and acid secretion to decrease. A reduction of Cl- conductance of the apical membrane, upon mucosal application of the drug, would cause similar effects on acid secretion and Cl- transport.
UR - http://www.scopus.com/inward/record.url?scp=0019294448&partnerID=8YFLogxK
U2 - 10.1152/ajpgi.1980.239.6.g532
DO - 10.1152/ajpgi.1980.239.6.g532
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AN - SCOPUS:0019294448
SN - 0193-1857
VL - 2
SP - G532-G535
JO - American Journal of Physiology - Gastrointestinal and Liver Physiology
JF - American Journal of Physiology - Gastrointestinal and Liver Physiology
IS - 6
ER -
