Suppressant effects of naltrexone on water intake in rats

Hanan Frenk*, Jeffrey B. Rosen

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Parenteral administration of naltrexone to water-deprived female rats suppressed water intake when injected 4, but not 12 hours prior to the drinking session. Intraperitoneal injection 5 mg/kg naltrexone twice daily or oral self-administration of naltrexone in doses sufficient to block morphine-induced analgesia failed to reduce water intake or to alter body weight in non-deprived animals. These findings suggest that the suppressant effects of naltrexone on appetitive behavior are mediated by a different population of opiate receptors than those mediating morphine-induced analgesia.

Original languageEnglish
Pages (from-to)387-390
Number of pages4
JournalPharmacology Biochemistry and Behavior
Issue number4
StatePublished - Oct 1979


  • Analgesia
  • Body weight
  • Morphine
  • Naltrexone
  • Opiate
  • Receptor
  • Water intake


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