Superoxide dismutase activity in Helicobacter pylori-positive antral gastritis in children

Efrat Broide*, Elieser Klinowski, Rina Varsano, Jerachmiel Eshchar, Mehrdad Herbert, Eitan Scapa

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Reactive oxygen metabolites have been implicated in gastric mucosal injuries. Superoxide dismutase, a scavenger of superoxide radical, is a key enzyme in gastric mucosal protection against several damaging factors. This study was aimed at investigating the relationship of superoxide dismutase activity to Helicobacter pylori-induced antral gastritis in children. Two groups of 11 children each, one positive and the other negative for Helicobacter pylori, were studied. Biopsies from the antrum and corpus were obtained for evaluation of Helicobacter pylori by CLOtest and histology as well as for superoxide dismutase activity (cytochrome c method). Erythrocyticand serum superoxide dismutase levels were determined as well. Superoxide dismutase activity was significantly higher only in the antrum of children with Helicobacter pylori-induced antral gastritis. There was no significant difference in superoxide dismutase activity in the corpus, erythrocytes, or serum of both groups. These findings may suggest a pathogenic relationship between the presence of Helicobacter pylori and oxygen radicals in inducing antral mucosal injury.

Original languageEnglish
Pages (from-to)609-613
Number of pages5
JournalJournal of Pediatric Gastroenterology and Nutrition
Volume23
Issue number5
DOIs
StatePublished - 1996
Externally publishedYes

Keywords

  • Children
  • Helicobacter pylori
  • Primary antral gastritis
  • Reactive oxygen metabolites
  • Superoxide dismutase

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