Superoxide anion production by neutrophils derived from peripheral blood of schizophrenic patients

Yuval Melamed, Pinkhas Sirota, Dror R. Dicker, Pnina Fishman

Research output: Contribution to journalArticlepeer-review

Abstract

Evidence indicates that excess free radicals formation may occur in patients with schizophrenia. A study comparing the production of superoxide anion by peripheral blood neutrophils of 29 schizophrenic patients with that of 17 healthy volunteers detected a significant statistical increase in superoxide anion production in schizophrenic patients compared to the healthy control group. Despite the fact that oxidative mechanisms may play a role in schizophrenia, further studies are needed to define their involvement. Such studies would shed light on the etiology and pathogenesis of schizophrenia and may lead to new therapeutic approaches using antioxidants, which might partially alleviate or prevent the symptoms of schizophrenia.

Original languageEnglish
Pages (from-to)29-34
Number of pages6
JournalPsychiatry Research
Volume77
Issue number1
DOIs
StatePublished - 16 Jan 1998

Keywords

  • Autoimmunity
  • Oxidative stress
  • Reactive oxygen species (ROS)
  • Schizophrenia

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