TY - JOUR
T1 - Superior Vena Cava Syndrome Associated With Lymphoma
AU - Yellin, Alon
AU - Mandel, Matilda
AU - Rechavi, Gideon
AU - Neuman, Yoram
AU - Ramot, Bracha
AU - Lieberman, Yair
PY - 1992/9
Y1 - 1992/9
N2 - To evaluate the workup and treatment of children with lymphoma and superior vena cava syndrome. —A retrospective survey. —State hospital serving as a secondary and tertiary referral center for pediatric oncology and pediatric cardiac surgery. —Eleven children aged 11 months to 12 years diagnosed as having lymphoma or T-cell acute lymphoblastic leukemia who presented with superior vena cava syndrome during an 11-year period. —Lymph node biopsy (two patients), thoracenthesis (five patients), bone marrow aspiration (two patients), and thoracenthesis in addition to bone marrow aspiration (two patients). All aspirates were evaluated with immunohistochemical studies. Chemotherapy was the only management intervention. —T-cell lymphoma or leukemia accounted for nine cases and Hodgkin's disease for two cases. Respiratory symptoms occurred in 10 patients, including tracheal compression in six patients (compression was life-threatening in one patient). Diagnosis of superior vena cava syndrome was achieved in eight patients using surface-marker analysis of aspirates. The syndrome disappeared within 2 to 10 days. Seven of nine children whose conditions were diagnosed more than 1 year before this writing were alive and free of disease after mean follow-up of 37 months. —(1) A specific diagnosis can be achieved in most children with superior vena cava syndrome and lymphoma; (2) Thoracic computed tomographic scans are essential, identifying minute pleural effusions that can aid diagnosis; (3) Anesthetic hazard is related only to severe tracheal compression; (4) Chemotherapy achieves excellent symptomatic relief; and (5) Long-term survival, without disease, is achievable.
AB - To evaluate the workup and treatment of children with lymphoma and superior vena cava syndrome. —A retrospective survey. —State hospital serving as a secondary and tertiary referral center for pediatric oncology and pediatric cardiac surgery. —Eleven children aged 11 months to 12 years diagnosed as having lymphoma or T-cell acute lymphoblastic leukemia who presented with superior vena cava syndrome during an 11-year period. —Lymph node biopsy (two patients), thoracenthesis (five patients), bone marrow aspiration (two patients), and thoracenthesis in addition to bone marrow aspiration (two patients). All aspirates were evaluated with immunohistochemical studies. Chemotherapy was the only management intervention. —T-cell lymphoma or leukemia accounted for nine cases and Hodgkin's disease for two cases. Respiratory symptoms occurred in 10 patients, including tracheal compression in six patients (compression was life-threatening in one patient). Diagnosis of superior vena cava syndrome was achieved in eight patients using surface-marker analysis of aspirates. The syndrome disappeared within 2 to 10 days. Seven of nine children whose conditions were diagnosed more than 1 year before this writing were alive and free of disease after mean follow-up of 37 months. —(1) A specific diagnosis can be achieved in most children with superior vena cava syndrome and lymphoma; (2) Thoracic computed tomographic scans are essential, identifying minute pleural effusions that can aid diagnosis; (3) Anesthetic hazard is related only to severe tracheal compression; (4) Chemotherapy achieves excellent symptomatic relief; and (5) Long-term survival, without disease, is achievable.
UR - http://www.scopus.com/inward/record.url?scp=0026733042&partnerID=8YFLogxK
U2 - 10.1001/archpedi.1992.02160210062022
DO - 10.1001/archpedi.1992.02160210062022
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C2 - 1514552
AN - SCOPUS:0026733042
SN - 0096-8994
VL - 146
SP - 1060
EP - 1063
JO - American Journal of Diseases of Children
JF - American Journal of Diseases of Children
IS - 9
ER -