Superficial siderosis of the central nervous system secondary to spinal ependymoma

Stylianos Pikis, José E. Cohen, Andres A. Vargas, J. Moshe Gomori, Sagi Harnof, Eyal Itshayek*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Superficial siderosis of the central nervous system is a syndrome caused by deposition of hemosiderin in the subpial layers of the central nervous system, occurring as a result of recurrent asymptomatic or symptomatic bleeding into the subarachnoid space. We report a rare case of superficial siderosis in a 33-year-old man who presented with sensorineural hearing loss. The diagnosis of superficial siderosis on MRI brain studies led to further investigations with detection of a spinal ependymoma at L1-L2, compressing the cauda equina. Gross total resection of the tumor arrested the progression of the neurological deterioration. Our report underlies the importance of early diagnosis and surgical management, with imaging examination of the full neuroaxis to identify the source of bleeding, to halt disease progression and improve prognosis.

Original languageEnglish
Pages (from-to)2017-2019
Number of pages3
JournalJournal of Clinical Neuroscience
Issue number11
StatePublished - 1 Nov 2014


  • Central nervous system
  • Spinal ependymoma
  • Superficial siderosis


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