TY - JOUR
T1 - 23Na, 59Co and 2H NMR studies of experimental acute pancreatitis
AU - Kushnir, Tammar
AU - Kaplan, Ofer
AU - Askenasy, Nadir
AU - Navon, Gil
PY - 1991/8
Y1 - 1991/8
N2 - Multinuclear MR was applied to the study of experimental acute pancreatitis. A continuous increase, up to 700%, of total, NMR visible, sodium content was detected during the development of the disease through the edematous stage to necrosis. The effect of the elevation of sodium content is amplified by an increased 23Na NMR visibility during the disease. Interstitial and total water volume of pancreases were estimated using the distribution of Co(CN)36 and D2O, by 50Co and 2H NMR, respectively. In healthy pancreases the interstitial compartment was found to comprise 35% of the tissue volume. In the diseased pancreases the penetration volume of Co(CN)36 reached 90% of the total tissue volume, indicating extensive membrane injury. The time dependence of the 23Na NMR in the presence of the shift reagent Na7Dy(tripolyphosphate)2.3NaCl provided additional evidence of the increased permeability of the membranes in the diseased organs.
AB - Multinuclear MR was applied to the study of experimental acute pancreatitis. A continuous increase, up to 700%, of total, NMR visible, sodium content was detected during the development of the disease through the edematous stage to necrosis. The effect of the elevation of sodium content is amplified by an increased 23Na NMR visibility during the disease. Interstitial and total water volume of pancreases were estimated using the distribution of Co(CN)36 and D2O, by 50Co and 2H NMR, respectively. In healthy pancreases the interstitial compartment was found to comprise 35% of the tissue volume. In the diseased pancreases the penetration volume of Co(CN)36 reached 90% of the total tissue volume, indicating extensive membrane injury. The time dependence of the 23Na NMR in the presence of the shift reagent Na7Dy(tripolyphosphate)2.3NaCl provided additional evidence of the increased permeability of the membranes in the diseased organs.
UR - http://www.scopus.com/inward/record.url?scp=0026209835&partnerID=8YFLogxK
U2 - 10.1002/nbm.1940040405
DO - 10.1002/nbm.1940040405
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AN - SCOPUS:0026209835
SN - 0952-3480
VL - 4
SP - 182
EP - 186
JO - NMR in Biomedicine
JF - NMR in Biomedicine
IS - 4
ER -