[18F]-FDG PET/CT in the staging and management of indolent lymphoma: A prospective multicenter PET registry study

Ur Metser, Jill Dudebout, Tara Baetz, David C. Hodgson, Deanna L. Langer, Pamela MacCrostie, Victor Mak, Noam Tau

Research output: Contribution to journalArticlepeer-review


BACKGROUND: To measure the clinical impact of pretreatment fludeoxyglucose positron emission tomography/computed tomography (PET/CT) on the staging and management of apparent limited stage indolent lymphoma being considered for curative radiation therapy. METHODS: We conducted a prospective multicenter registry study that included 197 patients accrued between May 1, 2012, and December 31, 2015. Pre-PET/CT stage, determined by clinical and CT data, was documented. If pre-PET/CT stage was indeterminate, a stage was assigned to the patient by the referring oncologist according to best clinical judgment and treatment intent. After PET/CT, revised stage and planned management were recorded and compared with data on actual treatment received available through provincial databases (n = 155). RESULTS: PET/CT resulted in the upstaging of 47 (23.9%) patients with presumed limited stage disease (stage I-II) to advanced stage disease (stage III-IV) (P <.0001). Ten (5.1%) patients were downstaged by PET/CT, 4 of whom migrated from advanced to limited stage disease. Twenty-eight (14.2%) patients with a specific pre-PET/CT stage had equivocal PET/CT findings that required further evaluation to confirm disease extent. After PET/CT, 95 (61.3%) patients were planned to receive active treatment. Of the 59 patients planned for radiotherapy alone post-PET/CT, 34 (57.6%) received this treatment (P =.002), and nearly 80% of them (n = 27) had confirmed limited stage disease. CONCLUSION: PET/CT has a significant impact on staging and management in patients with apparent limited stage indolent lymphoma who are being considered for curative radiotherapy. PET/CT should be routinely incorporated into the workup of these patients. Cancer 2017;123:2860–66.

Original languageEnglish
Pages (from-to)2860-2866
Number of pages7
Issue number15
StatePublished - 1 Aug 2017
Externally publishedYes


  • B-cell
  • chemoradiotherapy
  • follicular lymphoma
  • low-grade lymphoma
  • lymphoma
  • positron emission tomography computed tomography
  • radiotherapy
  • registries


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